ASPH and PRB2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ASPH	PRB2
Name		aspartate beta-hydroxylase	proline rich protein BstNI subfamily 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Extracellular Region
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity	Protein Binding
	Biological Process	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization	None
Pathways		Stimuli-sensing channels Ion homeostasis Protein hydroxylation	None
Drugs		Aspartic acid	None
GWAS		Blood protein levels ( 30072576 ) BRCA1/2-negative high-risk breast cancer ( 30323354 ) Resting heart rate ( 28270201 ) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592 ) Urate levels in overweight individuals ( 25811787 )	Alanine aminotransferase levels ( 33547301 ) Night sleep phenotypes ( 27126917 ) Periodontitis (CDC/AAP) ( 24024966 ) Response to gemcitabine in pancreatic cancer ( 22142827 ) Survival in pancreatic cancer ( 28470677 )
Novel Interactors		2 novel interactors: RAB2A STAG1	None recorded
Interacting Genes		73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16	2 interacting genes: ASPH MIEF2
Entrez ID		444	653247
HPRD ID		08996	Not available
Ensembl ID		ENSG00000198363	ENSG00000121335
Uniprot IDs		B4DQ07 B7ZM96 G3XAN5 Q12797	P02812
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9	Not available
GO Terms Enriched among Interactors		Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport	Activation Of Store-operated Calcium Channel Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Cortical Endoplasmic Reticulum Positive Regulation Of Establishment Of Protein Localization Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Protein Localization Positive Regulation Of Cation Channel Activity Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Mitochondrial Fission Mitochondrial Fusion Response To ATP Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Face Morphogenesis Regulation Of Mitochondrial Fission Regulation Of Protein Targeting To Membrane Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Transporter Activity Sarcoplasmic Reticulum Membrane Structural Constituent Of Muscle Regulation Of Cytosolic Calcium Ion Concentration Electron Transfer Activity Positive Regulation Of Calcium Ion Transmembrane Transport Sarcoplasmic Reticulum Dioxygenase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Regulation Of Cardiac Muscle Contraction Cellular Response To Calcium Ion Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Protein Depolymerization Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Calcium Ion Transport Regulation Of Striated Muscle Contraction Limb Morphogenesis Detection Of Chemical Stimulus Positive Regulation Of Cation Transmembrane Transport Regulation Of Mitochondrion Organization