ASPH and DCD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASPH	DCD
Description		aspartate beta-hydroxylase	dermcidin
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Extracellular Region Extracellular Space Membrane Extrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity	RNA Binding Monoatomic Ion Channel Activity Monoatomic Anion Channel Activity Protein Binding Peptidase Activity Lipid Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization	Proteolysis Inorganic Anion Transport Killing Of Cells Of Another Organism Monoatomic Ion Transmembrane Transport Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Monoatomic Anion Transmembrane Transport
Pathways		Stimuli-sensing channels Ion homeostasis Protein hydroxylation	Antimicrobial peptides
Drugs		Aspartic acid	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)	Type 2 diabetes ( 18372903)
Interacting Genes		73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16	8 interacting genes: APPBP2 ASPH CEBPA FOXP1 HSP90AA1 IL24 SUMO2 USP7
Entrez ID		444	117159
HPRD ID		08996	07363
Ensembl ID		ENSG00000198363	ENSG00000161634
Uniprot IDs		B4DQ07 B7ZM96 G3XAN5 Q12797	P81605
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9	2KSG 2NDK 2YMK 6SHK
Enriched GO Terms of Interacting Partners?		Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport	Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Muscle System Process Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding CTP Binding DATP Binding Regulation Of Protein Stability Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Cardiac Muscle Contraction Positive Regulation Of Intracellular Protein Transport Regulation Of Striated Muscle Contraction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Response To Vitamin B2 C/EBP Complex Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Interleukin-21 Production Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Telomere Maintenance PML Body Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Metabolic Process Regulation Of Cellular Localization CHOP-C/EBP Complex Response To Tumor Necrosis Factor Positive Regulation Of Proteasomal Protein Catabolic Process Rho GDP-dissociation Inhibitor Binding Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Establishment Of Protein Localization Transmembrane Transporter Binding Positive Regulation Of Intracellular Transport Regulation Of System Process Response To Peptide Histone Deacetylase Binding Response To Cytokine Positive Regulation Of Proteolysis Involved In Protein Catabolic Process White Fat Cell Proliferation Regulation Of Intracellular Protein Transport
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