GSC2 and BEST3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSC2	BEST3
Description		goosecoid homeobox 2	bestrophin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Plasma Membrane Membrane Chloride Channel Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Channel Activity Metal Ion Binding Ligand-gated Monoatomic Anion Channel Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis	Monoatomic Ion Transport Chloride Transport Inorganic Anion Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Chloride Transmembrane Transport
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Atrial fibrillation ( 29892015) Logical memory (delayed recall) in normal cognition ( 29274321) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587	1 interacting genes: GSC2
Entrez ID		2928	144453
HPRD ID		03506	09550
Ensembl ID		ENSG00000063515	ENSG00000127325
Uniprot IDs		O15499	Q8N1M1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Metabolic Process Response To Metal Ion Protein Phosphatase Activator Activity Calyx Of Held Protein Binding Catalytic Complex Negative Regulation Of Transporter Activity Response To Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Striated Muscle Contraction DNA Damage Response Spindle Microtubule Negative Regulation Of Monoatomic Ion Transport Nucleic Acid Metabolic Process Presynaptic Endocytosis Substantia Nigra Development Sarcoplasmic Reticulum Lumen Calcium Channel Regulator Activity Detection Of Chemical Stimulus Sperm Midpiece Adenylate Cyclase Binding Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Nucleobase-containing Compound Metabolic Process
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