GSC2 and UBE2R2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSC2	UBE2R2
Description		goosecoid homeobox 2	ubiquitin conjugating enzyme E2 R2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)
Interacting Genes		60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587	26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC
Entrez ID		2928	54926
HPRD ID		03506	15602
Ensembl ID		ENSG00000063515	ENSG00000107341
Uniprot IDs		O15499	Q712K3
PDB IDs			6NYO 8PQL 8Q7R 8R5H
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Metabolic Process Response To Metal Ion Protein Phosphatase Activator Activity Calyx Of Held Protein Binding Catalytic Complex Negative Regulation Of Transporter Activity Response To Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Striated Muscle Contraction DNA Damage Response Spindle Microtubule Negative Regulation Of Monoatomic Ion Transport Nucleic Acid Metabolic Process Presynaptic Endocytosis Substantia Nigra Development Sarcoplasmic Reticulum Lumen Calcium Channel Regulator Activity Detection Of Chemical Stimulus Sperm Midpiece Adenylate Cyclase Binding Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Nucleobase-containing Compound Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Ubiquitin Protein Ligase Binding Transferase Activity Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization SCF Ubiquitin Ligase Complex Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Autoubiquitination Regulation Of Programmed Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction
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