CCDC88C and DVL1

Number of citations of the paper that reports this interaction (PMID 14750955)
4

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CCDC88C	DVL1
Gene Name		coiled-coil domain containing 88C	dishevelled segment polarity protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol Microtubule Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Synapse
	Molecular Function	PDZ Domain Binding Protein Self-association	Molecular_function Frizzled Binding Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Rac GTPase Binding
	Biological Process	Regulation Of Protein Phosphorylation Wnt Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Protein Destabilization Protein Homooligomerization	Regulation Of Neurotransmitter Levels Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Wnt Signaling Pathway Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Receptor Clustering Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by WNT in cancer	disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		5 interactors: APP DVL1 GNAI3 ITSN2 MAPK8	35 interactors: ANXA7 ARRB1 ATN1 AXIN1 BRD7 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FRAT1 HDHD2 HECW1 LRRK2 NCK2 NEDD4 PPM1A PSMA3 RAC1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 TRIM69 USP13 VANGL1 VANGL2
Entrez ID		440193	1855
HPRD ID		19136	03220
Ensembl ID		ENSG00000015133	ENSG00000107404
Uniprot IDs		B4DZB8 Q9P219	O14640 Q86TH3
PDB IDs
Enriched GO Terms of Interacting Partners?		Collateral Sprouting Regulation Of Protein Binding Regulation Of Catalytic Activity Regulation Of Binding Neuromuscular Junction Development Negative Regulation Of Protein Binding Developmental Cell Growth Negative Regulation Of Binding Neuromuscular Process Negative Regulation Of Catalytic Activity Dendrite Development Developmental Growth Involved In Morphogenesis Cell Growth Synaptic Growth At Neuromuscular Junction Synapse Organization Convergent Extension Involved In Neural Plate Elongation Collateral Sprouting In Absence Of Injury Platelet Activation Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Axon Midline Choice Point Recognition JUN Phosphorylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Deacetylase Activity Convergent Extension Involved In Organogenesis Regulation Of Signaling Axon Choice Point Recognition Developmental Growth Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of Determination Of Dorsal Identity Protein Localization To Microtubule Neural Plate Morphogenesis Neuron Remodeling Positive Regulation Of Metabolic Process Response To Light Stimulus Vesicle-mediated Transport Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Axon Guidance Cellular Response To Nitric Oxide Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Response To Oxidative Stress Blood Coagulation Hemostasis Convergent Extension	Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Morphogenesis Regulation Of Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process SMAD Protein Complex Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Proteasomal Protein Catabolic Process Cell Communication Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Stem Cell Differentiation Embryonic Axis Specification Regulation Of Phosphorus Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Kidney Development
Tagcloud ?		ataxia ataxias atrophy autosomal causative cerebellar cerebellum characterised coil coiled congenital cure dominant exhibits exome expands g1391a genetically jnk missense neurological pontocerebellar r464h sca scas spinocerebellar triggers unveils	1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic
Tagcloud (Difference) ?		ataxia ataxias atrophy autosomal causative cerebellar cerebellum characterised coil coiled congenital cure dominant exhibits exome expands g1391a genetically jnk missense neurological pontocerebellar r464h sca scas spinocerebellar triggers unveils	1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic
Tagcloud (Intersection) ?