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CCDC88C
Gene Name
coiled-coil domain containing 88C
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Molecular Function
PDZ Domain Binding
Protein Self-association
Biological Process
Regulation Of Protein Phosphorylation
Wnt Signaling Pathway
Stress-activated Protein Kinase Signaling Cascade
Protein Destabilization
Protein Homooligomerization
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Breast cancer (
23535729
)
Protein-protein Interactions
5 interactors:
APP
DVL1
GNAI3
ITSN2
MAPK8
Entrez ID
440193
HPRD ID
19136
Ensembl ID
ENSG00000015133
Uniprot IDs
B4DZB8
Q9P219
PDB IDs
Enriched GO Terms of Interacting Partners
?
Collateral Sprouting
Regulation Of Protein Binding
Regulation Of Catalytic Activity
Regulation Of Binding
Neuromuscular Junction Development
Negative Regulation Of Protein Binding
Developmental Cell Growth
Negative Regulation Of Binding
Neuromuscular Process
Negative Regulation Of Catalytic Activity
Dendrite Development
Developmental Growth Involved In Morphogenesis
Cell Growth
Synaptic Growth At Neuromuscular Junction
Synapse Organization
Convergent Extension Involved In Neural Plate Elongation
Collateral Sprouting In Absence Of Injury
Platelet Activation
Positive Regulation Of Hydrolase Activity
Regulation Of Signal Transduction
Axon Midline Choice Point Recognition
JUN Phosphorylation
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Deacetylase Activity
Convergent Extension Involved In Organogenesis
Regulation Of Signaling
Axon Choice Point Recognition
Developmental Growth
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Proteolysis
Positive Regulation Of Determination Of Dorsal Identity
Protein Localization To Microtubule
Neural Plate Morphogenesis
Neuron Remodeling
Positive Regulation Of Metabolic Process
Response To Light Stimulus
Vesicle-mediated Transport
Skeletal Muscle Acetylcholine-gated Channel Clustering
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Catalytic Activity
Positive Regulation Of Gene Expression
Axon Guidance
Cellular Response To Nitric Oxide
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure
Response To Oxidative Stress
Blood Coagulation
Hemostasis
Convergent Extension
Tagcloud
?
ataxia
ataxias
atrophy
autosomal
causative
cerebellar
cerebellum
characterised
coil
coiled
congenital
cure
dominant
exhibits
exome
expands
g1391a
genetically
jnk
missense
neurological
pontocerebellar
r464h
sca
scas
spinocerebellar
triggers
unveils