CD200 and HUS1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CD200	HUS1
Name		CD200 molecule	HUS1 checkpoint clamp component
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Glycosylated Region Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
GWAS		Basal cell carcinoma ( 33549134 ) Blood protein levels ( 30072576 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Sum eosinophil basophil counts ( 27863252 )	Gut microbiota alpha diversity (Shannon index) ( 33208821 ) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507 )
Novel Interactors		7 novel interactors: CASR CFAP91 MAST2 PLOD1 TMEM11 TMEM147 ZNF652	None recorded
Interacting Genes		3 interacting genes: CD200R1 HCRTR2 HUS1	28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ
Entrez ID		4345	3364
HPRD ID		01124	04787
Ensembl ID		ENSG00000091972	ENSG00000136273
Uniprot IDs		B4DDZ6 F8W7G1 P41217 U3KQQ2	A4D2F2 O60921
PDB IDs		Not available	3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
GO Terms Enriched among Interactors		None	DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination