CD200 and CASR

Data Source: HiPPIP (Novel)

		CD200	CASR
Name		CD200 molecule	calcium sensing receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Presynaptic Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Glycosylated Region Protein Binding	G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration	Ossification Response To Ischemia Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Response To Metal Ion Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Response To Calcium Ion Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Regulation Of Presynaptic Membrane Potential Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		None	Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate
Diseases		None	Bartter syndrome
GWAS		Basal cell carcinoma ( 33549134 ) Blood protein levels ( 30072576 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Sum eosinophil basophil counts ( 27863252 )	Calcium levels ( 20661308 20705733 24068962 29403010 25886283 25972035 ) Cardiac Troponin-T levels ( 23247143 ) Chronic widespread musculoskeletal pain ( 33331911 ) Clinical laboratory measurements ( 27897004 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Kidney stones ( 26272126 ) Metabolite levels ( 31628463 ) Phosphorus levels ( 20558539 ) Psoriasis ( 25854761 ) QT interval ( 29874175 ) Serum parathyroid hormone levels ( 27927781 ) Type 2 diabetes ( 30718926 32499647 )
Novel Interactors		7 novel interactors: CASR CFAP91 MAST2 PLOD1 TMEM11 TMEM147 ZNF652	2 novel interactors: CD200 TCF4
Interacting Genes		3 interacting genes: CD200R1 HCRTR2 HUS1	11 interacting genes: FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL
Entrez ID		4345	846
HPRD ID		01124	03122
Ensembl ID		ENSG00000091972	ENSG00000036828
Uniprot IDs		B4DDZ6 F8W7G1 P41217 U3KQQ2	P41180
PDB IDs		Not available	5FBH 5FBK 5K5S 5K5T 7DTT 7DTU 7DTV 7DTW 7E6T 7E6U 7M3E 7M3F 7M3G 7M3J 7SIL 7SIM 7SIN 8SZF 8SZG 8SZH 8SZI 8WPG 8WPU 9ASB 9AVG 9AVL 9AXF 9AYF 9C1P 9C2F 9J7I
GO Terms Enriched among Interactors		None	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Secretion By Cell Regulation Of Secretion Protein Kinase C Signaling Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Exocytosis Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Synaptic Signaling Via Neuropeptide Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Transcription Regulator Activator Activity Mitotic Nuclear Membrane Disassembly Regulation Of Programmed Cell Death Positive Regulation Of Insulin Secretion Regulation Of Protein Secretion Regulation Of Neural Precursor Cell Proliferation Regulation Of Signal Transduction Regulation Of Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Regulation Of Cell Population Proliferation Positive Regulation Of Peptide Secretion Regulation Of Blood Vessel Endothelial Cell Migration Calyx Of Held Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Hypoxia Glandular Epithelial Cell Differentiation Cellular Response To Decreased Oxygen Levels Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Enzyme Binding Plasma Membrane Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Biomineral Tissue Development Presynaptic Cytosol Cellular Response To Oxygen Levels