CD200 and CD200R1

Number of citations of the paper that reports this interaction (PubMedID 10981966)
0

Data Source:
HPRD (in vivo, in vitro)

		CD200	CD200R1
Description		CD200 molecule	CD200 receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Glycosylated Region Protein Binding	Protein Binding Immunoglobulin Receptor Activity Signaling Receptor Activity Glycosylated Region Protein Binding
	Biological Process	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration	Signal Transduction Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Blood protein levels ( 30072576) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Asthma ( 32296059) Blood protein levels ( 30072576) Economic and political preferences ( 22566634) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neurological blood protein biomarker levels ( 31320639) Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		3 interacting genes: CD200R1 HCRTR2 HUS1	9 interacting genes: ADIPOQ CD200 CLDN19 ERMP1 GALNT15 NINJ1 PTCH1 SFTPC SGTB
Entrez ID		4345	131450
HPRD ID		01124	09609
Ensembl ID		ENSG00000091972	ENSG00000163606
Uniprot IDs		B4DDZ6 F8W7G1 P41217 U3KQQ2	Q8TD46
PDB IDs			9GWT
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Cell Population Proliferation Cell-cell Adhesion Mediator Activity Negative Regulation Of Cell Migration Heterotypic Cell-cell Adhesion Ferroptosis Neural Plate Axis Specification Positive Regulation Of Cholesterol Efflux Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Inflammatory Response Response To Chlorate Positive Regulation Of Lipid Transport Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress TRC Complex Mesaxon Regulation Of Cell Motility Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Locomotion Glycosylated Region Protein Binding Hedgehog Family Protein Binding Hedgehog Receptor Activity Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Cell-cell Adhesion Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of Protein Transport Regeneration Membrane Destabilizing Activity Epidermal Cell Fate Specification Smoothened Binding Localization Within Membrane Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Regulation Of Transepithelial Transport Negative Regulation Of Establishment Of Protein Localization Regulation Of Lipid Transport Regulation Of Mononuclear Cell Migration Negative Regulation Of Secretion By Cell Regulation Of Cholesterol Import
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