MC2R

Gene Name		melanocortin 2 receptor (adrenocorticotropic hormone)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding
	Biological Process	Placenta Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes
Drugs		Cosyntropin Corticotropin
Diseases
GWAS
Protein-protein Interactions		2 interactors: ASIP POMC
Entrez ID		4158
HPRD ID		06304
Ensembl ID		ENSG00000185231
Uniprot IDs		Q01718
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Pigmentation Pigmentation Regulation Of Molecular Function, Epigenetic Regulation Of Corticosterone Secretion Generation Of Precursor Metabolites And Energy Adult Feeding Behavior Melanin Biosynthetic Process Cell-cell Signaling Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Secondary Metabolite Biosynthetic Process Pigment Granule Organization Genetic Imprinting Melanosome Transport Peptide Hormone Processing Pigment Granule Transport Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Melanosome Localization Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Pigment Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Lipid Transport Neuropeptide Signaling Pathway Regulation Of Tumor Necrosis Factor Production Feeding Behavior Phenol-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Hormone-mediated Signaling Pathway Peptide Metabolic Process Regulation Of Carbohydrate Metabolic Process Adult Behavior Regulation Of Blood Pressure Hormone Metabolic Process Establishment Of Vesicle Localization Glucose Homeostasis Negative Regulation Of Cytokine Production Vesicle Organization Vesicle Localization
Tagcloud ?		acth adrenocorticotropic ancestry collaborative constitute contributions corticotropin cortisol critical critically employing eunice ga genotype gestation gg ill illness kennedy nucleotide observational pediatric personalized portion rs1941088 shriver tag variability varies