MC2R and MRAP

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MC2R	MRAP
Description		melanocortin 2 receptor	melanocortin 2 receptor accessory protein
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding	Protein Binding Signaling Receptor Regulator Activity Corticotropin Hormone Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Identical Protein Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway	Protein Localization To Plasma Membrane Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes obesity and POMCD
Drugs		Tetracosactide Corticotropin Seractide acetate Bremelanotide
Diseases		Adrenal carcinoma
GWAS		Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		4 interacting genes: ASIP MRAP MRAP2 POMC	1 interacting genes: MC2R
Entrez ID		4158	56246
HPRD ID		06304	10758
Ensembl ID		ENSG00000185231	ENSG00000170262
Uniprot IDs		Q01718	Q8TCY5
PDB IDs		8GY7	8GY7
Enriched GO Terms of Interacting Partners?		Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Type 5 Melanocortin Receptor Binding Corticotropin Hormone Receptor Binding Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Signaling Receptor Regulator Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Generation Of Precursor Metabolites And Energy Pigmentation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Feeding Behavior Melanocortin Receptor Binding Positive Regulation Of Oxytocin Production Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Membrane Protein Localization To Plasma Membrane Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Negative Regulation Of Protein Localization Protein Localization To Cell Periphery Regulation Of Corticosterone Secretion Regulation Of Neutrophil Mediated Cytotoxicity Protein Localization To Membrane Positive Regulation Of Melanin Biosynthetic Process Adult Feeding Behavior Melanin Biosynthetic Process Positive Regulation Of Signal Transduction Signaling Receptor Binding Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pigment Granule Localization Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Regulation Of Appetite Localization Within Membrane Regulation Of Cellular Localization Neuropeptide Hormone Activity	Corticotropin Receptor Activity Melanocortin Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
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