MC2R and ASIP

Number of citations of the paper that reports this interaction (PMID 9058374)
19

Data Source:
HPRD (in vitro)

		MC2R	ASIP
Gene Name		melanocortin 2 receptor (adrenocorticotropic hormone)	agouti signaling protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space
	Molecular Function	Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding	Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	Placenta Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Genetic Imprinting
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes
Drugs		Cosyntropin Corticotropin
Diseases
GWAS			Breast cancer ( 22976474) Burning and freckling ( 18488028) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Melanoma ( 21983787) Red vs. non-red hair color ( 18488028) Skin sensitivity to sun ( 18488028) Tanning ( 23548203)
Protein-Protein Interactions		2 interactors: ASIP POMC	6 interactors: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		4158	434
HPRD ID		06304	02562
Ensembl ID		ENSG00000185231	ENSG00000101440
Uniprot IDs		Q01718	P42127
PDB IDs			1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?		Cellular Pigmentation Pigmentation Regulation Of Molecular Function, Epigenetic Regulation Of Corticosterone Secretion Generation Of Precursor Metabolites And Energy Adult Feeding Behavior Melanin Biosynthetic Process Cell-cell Signaling Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Secondary Metabolite Biosynthetic Process Pigment Granule Organization Genetic Imprinting Melanosome Transport Peptide Hormone Processing Pigment Granule Transport Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Melanosome Localization Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Pigment Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Lipid Transport Neuropeptide Signaling Pathway Regulation Of Tumor Necrosis Factor Production Feeding Behavior Phenol-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Hormone-mediated Signaling Pathway Peptide Metabolic Process Regulation Of Carbohydrate Metabolic Process Adult Behavior Regulation Of Blood Pressure Hormone Metabolic Process Establishment Of Vesicle Localization Glucose Homeostasis Negative Regulation Of Cytokine Production Vesicle Organization Vesicle Localization	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Feeding Behavior Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Homoiothermy Regulation Of Blood Pressure Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Protein Kinase A Signaling UV-damage Excision Repair Establishment Of Endothelial Intestinal Barrier Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Response To Stimulus Regulation Of Grooming Behavior Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Rho GTPase Activity UV Protection Positive Regulation Of Bone Resorption Regulation Of Protein Kinase A Signaling Positive Regulation Of Rap GTPase Activity Regulation Of Protein Kinase C Signaling Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Negative Regulation Of Ras GTPase Activity Response To Radiation Regulation Of Rap GTPase Activity Secondary Metabolite Biosynthetic Process Intestinal Absorption Sodium Ion Homeostasis Temperature Homeostasis Regulation Of Rap Protein Signal Transduction
Tagcloud ?		acth adrenocorticotropic ancestry collaborative constitute contributions corticotropin cortisol critical critically employing eunice ga genotype gestation gg ill illness kennedy nucleotide observational pediatric personalized portion rs1941088 shriver tag variability varies	agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		acth adrenocorticotropic ancestry collaborative constitute contributions corticotropin cortisol critical critically employing eunice ga genotype gestation gg ill illness kennedy nucleotide observational pediatric personalized portion rs1941088 shriver tag variability varies	agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?