MMP9 and TIMP3

Number of citations of the paper that reports this interaction (PubMedID 11827795)
0

Data Source:
HPRD (in vivo, in vitro)

		MMP9	TIMP3
Description		matrix metallopeptidase 9	TIMP metallopeptidase inhibitor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Basement Membrane Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Secretory Granule Lumen
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Skeletal System Development Positive Regulation Of Protein Phosphorylation Proteolysis Apoptotic Process Embryo Implantation Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Keratinocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Negative Regulation Of Cation Transmembrane Transport Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Visual Perception Response To Hormone Negative Regulation Of Extracellular Matrix Disassembly Response To Cytokine Negative Regulation Of Proteolysis Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Pathways		Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling	Platelet degranulation
Drugs		Glutathione Marimastat Minocycline Captopril Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Oleandrin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Pimagedine
Diseases		Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)	Sorsby fundus dystrophy
GWAS		Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 21665990 23455636) Alzheimer's disease progression score ( 29860282) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)
Interacting Genes		32 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFBI THBS1 THBS2 TIMP3	8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9
Entrez ID		4318	7078
HPRD ID		00387	01785
Ensembl ID		ENSG00000100985	ENSG00000100234
Uniprot IDs		P14780	P35625
PDB IDs		1GKC 1GKD 1ITV 1L6J 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM 8K5V 8K5W 8K5X 8K5Y	3CKI
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Protease Binding Collagen Metabolic Process Angiogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Platelet-derived Growth Factor Binding Cell Surface Receptor Signaling Pathway Endopeptidase Inhibitor Activity CXCR Chemokine Receptor Binding Extracellular Matrix Disassembly Peptidase Inhibitor Activity Metalloendopeptidase Inhibitor Activity Chemokine Activity Response To Amino Acid Regulation Of Anatomical Structure Morphogenesis Collagen Type I Trimer Inflammatory Response Positive Regulation Of Cell Migration Humoral Immune Response Regulation Of Blood Coagulation Positive Regulation Of Cell Motility Regulation Of Hemostasis Heparin Binding Response To Lipid Cellular Response To Growth Factor Stimulus Positive Regulation Of Locomotion Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Lipopolysaccharide Serine-type Endopeptidase Inhibitor Activity Cellular Response To Lipid Cellular Response To Fibroblast Growth Factor Stimulus Defense Response	Endopeptidase Activity Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Extracellular Matrix Disassembly Collagen Metabolic Process Serine-type Endopeptidase Activity Extracellular Matrix Cellular Response To UV-A Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidase Activity Response To Amyloid-beta Response To UV-A Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Endodermal Cell Differentiation Protein Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Ovarian Follicle Development Animal Organ Morphogenesis Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Proteolysis Post-embryonic Eye Morphogenesis Animal Organ Development Cellular Response To UV Extracellular Space Cellular Response To Light Stimulus Hydrolase Activity Cell Migration Ossification Integrin Binding Macromolecule Metabolic Process Cell Motility Response To UV Cellular Response To Radiation Cell Surface Receptor Signaling Pathway Extracellular Region Endochondral Ossification Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation
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