MMP9 and MMP26

Number of citations of the paper that reports this interaction (PubMedID 12586837)
0

Data Source:
HPRD (in vivo)

		MMP9	MMP26
Description		matrix metallopeptidase 9	matrix metallopeptidase 26
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Positive Regulation Of Protein Phosphorylation Proteolysis Apoptotic Process Embryo Implantation Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Keratinocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Negative Regulation Of Cation Transmembrane Transport Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Inflammatory Response
Pathways		Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling
Drugs		Glutathione Marimastat Minocycline Captopril Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Oleandrin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Marimastat
Diseases		Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)	Coenzyme Q10 levels ( 27149984) Malaria ( 31844061) Mean corpuscular volume ( 28453575)
Interacting Genes		32 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFBI THBS1 THBS2 TIMP3	4 interacting genes: ERRFI1 IGFBP1 MMP9 SERPINA1
Entrez ID		4318	56547
HPRD ID		00387	05683
Ensembl ID		ENSG00000100985	ENSG00000167346
Uniprot IDs		P14780	A0A8J8YUH5 Q9NRE1
PDB IDs		1GKC 1GKD 1ITV 1L6J 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM 8K5V 8K5W 8K5X 8K5Y
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Protease Binding Collagen Metabolic Process Angiogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Platelet-derived Growth Factor Binding Cell Surface Receptor Signaling Pathway Endopeptidase Inhibitor Activity CXCR Chemokine Receptor Binding Extracellular Matrix Disassembly Peptidase Inhibitor Activity Metalloendopeptidase Inhibitor Activity Chemokine Activity Response To Amino Acid Regulation Of Anatomical Structure Morphogenesis Collagen Type I Trimer Inflammatory Response Positive Regulation Of Cell Migration Humoral Immune Response Regulation Of Blood Coagulation Positive Regulation Of Cell Motility Regulation Of Hemostasis Heparin Binding Response To Lipid Cellular Response To Growth Factor Stimulus Positive Regulation Of Locomotion Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Lipopolysaccharide Serine-type Endopeptidase Inhibitor Activity Cellular Response To Lipid Cellular Response To Fibroblast Growth Factor Stimulus Defense Response	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Embryo Implantation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Response To Insulin Ficolin-1-rich Granule Lumen Regulation Of Epithelial Cell Differentiation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Skeletal System Development Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Negative Regulation Of Signal Transduction Insulin-like Growth Factor I Binding Response To Peptide Hormone Negative Regulation Of Cell Communication Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Negative Regulation Of Signaling Extracellular Space Endoplasmic Reticulum Lumen Response To UV-A Positive Regulation Of Keratinocyte Migration Regulation Of Protein Phosphorylation Cellular Response To UV-A Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Limb Joint Morphogenesis Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Extracellular Matrix Regulation Of Phosphorylation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Lung Epithelium Development Cellular Response To Lipid Cellular Hyperosmotic Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of DNA Binding Cellular Response To Platelet-derived Growth Factor Stimulus
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