MMP9 and CXCL1

Number of citations of the paper that reports this interaction (PubMedID 11023497)
0

Data Source:
HPRD (in vitro)

		MMP9	CXCL1
Description		matrix metallopeptidase 9	C-X-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity
	Biological Process	Skeletal System Development Positive Regulation Of Protein Phosphorylation Proteolysis Apoptotic Process Embryo Implantation Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Keratinocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Negative Regulation Of Cation Transmembrane Transport Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Killing Of Cells Of Another Organism Intracellular Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation
Drugs		Glutathione Marimastat Minocycline Captopril Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Oleandrin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)	Anxiety disorder ( 25390645) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)
Interacting Genes		32 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFBI THBS1 THBS2 TIMP3	13 interacting genes: ACKR1 CCL11 CXCL5 CXCL6 CXCR1 CXCR2 ESR1 HIPK2 HRAS MEOX2 MMP9 PTEN XRCC3
Entrez ID		4318	2919
HPRD ID		00387	01119
Ensembl ID		ENSG00000100985	ENSG00000163739
Uniprot IDs		P14780	P09341
PDB IDs		1GKC 1GKD 1ITV 1L6J 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM 8K5V 8K5W 8K5X 8K5Y	1MGS 1MSG 1MSH 1ROD 8K4O 8XWA 8XWV
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Protease Binding Collagen Metabolic Process Angiogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Platelet-derived Growth Factor Binding Cell Surface Receptor Signaling Pathway Endopeptidase Inhibitor Activity CXCR Chemokine Receptor Binding Extracellular Matrix Disassembly Peptidase Inhibitor Activity Metalloendopeptidase Inhibitor Activity Chemokine Activity Response To Amino Acid Regulation Of Anatomical Structure Morphogenesis Collagen Type I Trimer Inflammatory Response Positive Regulation Of Cell Migration Humoral Immune Response Regulation Of Blood Coagulation Positive Regulation Of Cell Motility Regulation Of Hemostasis Heparin Binding Response To Lipid Cellular Response To Growth Factor Stimulus Positive Regulation Of Locomotion Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Lipopolysaccharide Serine-type Endopeptidase Inhibitor Activity Cellular Response To Lipid Cellular Response To Fibroblast Growth Factor Stimulus Defense Response	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Myeloid Leukocyte Migration Positive Regulation Of Cell Population Proliferation Chemotaxis Leukocyte Chemotaxis Neutrophil Chemotaxis Locomotion Neutrophil Migration Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Leukocyte Migration Interleukin-8 Receptor Activity C-C Chemokine Binding Cell Migration Interleukin-8 Binding Cell Motility Regulation Of Cell Population Proliferation Chemokine Activity Cytokine-mediated Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway C-X-C Chemokine Receptor Activity Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Inflammatory Response CXCR Chemokine Receptor Binding Dendritic Cell Chemotaxis Response To Stress Branching Involved In Mammary Gland Duct Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Intracellular Signal Transduction Immune Response Chemokine Receptor Activity C-C Chemokine Receptor Activity Dendritic Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Antimicrobial Humoral Response Defense Response Cellular Response To Lipopolysaccharide Negative Regulation Of Apoptotic Process Cellular Response To Lipid Negative Regulation Of Programmed Cell Death Cellular Response To Molecule Of Bacterial Origin Fibroblast Proliferation Cytokine Activity Regulation Of Cell Migration Regulation Of Cell Motility
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?