THBS2 and MMP9

Number of citations of the paper that reports this interaction (PubMedID 10900205)
0

Data Source:
HPRD (two hybrid, in vitro)

		THBS2	MMP9
Description		thrombospondin 2	matrix metallopeptidase 9
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Platelet Alpha Granule	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Cell Adhesion Negative Regulation Of Angiogenesis Positive Regulation Of Synapse Assembly	Skeletal System Development Positive Regulation Of Protein Phosphorylation Proteolysis Apoptotic Process Embryo Implantation Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Keratinocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Negative Regulation Of Cation Transmembrane Transport Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by PDGF Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling
Drugs			Glutathione Marimastat Minocycline Captopril Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Oleandrin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Anorectal malformation ( 31136621) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Carotid intima media thickness x smoking interaction ( 32117412) Central corneal thickness ( 29760442 32528159) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Copper levels ( 26025379) Dimensional psychopathology (Cognitive) ( 29496196) Haemorrhoidal disease ( 33888516) Joint mobility (Beighton score) ( 27182965) Liver disease severity in Alagille syndrome ( 28090565) Obesity-related traits ( 23251661) Pulse pressure ( 27841878 28135244)	Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)
Interacting Genes		4 interacting genes: MMP2 MMP9 THBS3 UBC	32 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFBI THBS1 THBS2 TIMP3
Entrez ID		7058	4318
HPRD ID		01766	00387
Ensembl ID		ENSG00000186340	ENSG00000100985
Uniprot IDs		A0A7I2V585 P35442	P14780
PDB IDs		1YO8 2RHP	1GKC 1GKD 1ITV 1L6J 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM 8K5V 8K5W 8K5X 8K5Y
Enriched GO Terms of Interacting Partners?		Cellular Response To UV-A Bone Trabecula Formation Response To UV-A Collagen Catabolic Process Embryo Implantation Endodermal Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Extracellular Matrix Response To Amyloid-beta Collagen Metabolic Process Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Endopeptidase Activity Cellular Response To UV Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Apoptotic Process Metalloendopeptidase Activity Positive Regulation Of Programmed Cell Death Cellular Response To Light Stimulus Ossification Metallopeptidase Activity Brain Renin-angiotensin System Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Developmental Maturation Intramembranous Ossification Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Extracellular Matrix Organization Blood Vessel Maturation Extracellular Structure Organization Peripheral Nervous System Axon Regeneration Trophoblast Cell Migration Ovulation From Ovarian Follicle Heart Development Luteinization Parturition Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Meiotic Nuclear Division Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Ossification Involved In Bone Maturation Proteolysis Positive Regulation Of Keratinocyte Migration	Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Protease Binding Collagen Metabolic Process Angiogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Platelet-derived Growth Factor Binding Cell Surface Receptor Signaling Pathway Endopeptidase Inhibitor Activity CXCR Chemokine Receptor Binding Extracellular Matrix Disassembly Peptidase Inhibitor Activity Metalloendopeptidase Inhibitor Activity Chemokine Activity Response To Amino Acid Regulation Of Anatomical Structure Morphogenesis Collagen Type I Trimer Inflammatory Response Positive Regulation Of Cell Migration Humoral Immune Response Regulation Of Blood Coagulation Positive Regulation Of Cell Motility Regulation Of Hemostasis Heparin Binding Response To Lipid Cellular Response To Growth Factor Stimulus Positive Regulation Of Locomotion Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Lipopolysaccharide Serine-type Endopeptidase Inhibitor Activity Cellular Response To Lipid Cellular Response To Fibroblast Growth Factor Stimulus Defense Response
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