COL6A3 and GFRA3

		COL6A3	GFRA3
Description		collagen type VI alpha 3 chain	GDNF family receptor alpha 3
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Sarcolemma Extracellular Exosome Extracellular Vesicle	Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Receptor Complex Side Of Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Peptidase Inhibitor Activity	Signaling Receptor Binding Protein Binding Axon Guidance Receptor Activity Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	Cell Adhesion Muscle Organ Development Response To UV Response To Glucose Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Apoptotic Process	Neuron Migration Signal Transduction Nervous System Development Axon Guidance Peripheral Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	RAF/MAP kinase cascade RET signaling
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Abstraction and mental flexibility ( 31596458) Aging (time to event) ( 21782286) Chronic kidney disease ( 30226566) Coronary artery disease ( 33020668 29212778 30402224) Cortex volume ( 31530798) HDL cholesterol ( 26160806) Heel bone mineral density ( 30598549) Height ( 33713608) Hypertension ( 30226566) Intraocular pressure ( 29617998 29235454) Ischemic stroke ( 29930801) LDL cholesterol ( 26160806) Lung cancer ( 28604730) Myocardial infarction ( 30226566) Pulse pressure ( 27841878)	Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) QT interval ( 24952745) Schizophrenia ( 25056061)
Interacting Genes		2 interacting genes: DYSF MMP2	1 interacting genes: ARTN
Entrez ID		1293	2676
HPRD ID		00371	10420
Ensembl ID		ENSG00000163359	ENSG00000146013
Uniprot IDs		B7ZW00 D9ZGF2 P12111 Q8N4Z1	O60609
PDB IDs		1KNT 1KTH 1KUN 2KNT 6SNK	2GH0 6Q2S
Enriched GO Terms of Interacting Partners?			Collagen Type VI Trimer Glial Cell-derived Neurotrophic Factor Receptor Binding Peyer's Patch Morphogenesis Lymphocyte Migration Into Lymphoid Organs Induction Of Positive Chemotaxis Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Positive Chemotaxis Peripheral Nervous System Development Extracellular Matrix Structural Constituent Conferring Tensile Strength Neuroblast Proliferation Extracellular Space Lymphocyte Migration Receptor Tyrosine Kinase Binding Neuron Apoptotic Process Extracellular Region Peptidase Inhibitor Activity Muscle Organ Development Sarcolemma Muscle Structure Development Collagen Trimer Serine-type Endopeptidase Inhibitor Activity Extracellular Vesicle Response To Monosaccharide Response To Glucose Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neural Precursor Cell Proliferation Positive Regulation Of Chemotaxis Mononuclear Cell Migration Response To UV Response To Carbohydrate Growth Factor Activity
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