MLLT3 and MCM6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		MLLT3	MCM6
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	minichromosome maintenance complex component 6
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Gene Ontology Annotations	Cellular Component	Nucleus Transcription Elongation Factor Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm MCM Complex
	Molecular Function	Protein Binding	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Segment Specification Anterior/posterior Pattern Specification Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways			Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AFF1 APP APPBP2 BCOR CBX8 CDK6 EEF1A1 LRIF1 MCM6 PTN RBM48 SGK1	31 interactors: ALS2CR11 CCNA1 CDC45 CDC7 CDKN2A CDT1 CRLS1 DBF4 FAM161A GMNN HDAC1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MLLT3 NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 ZBTB9
Entrez ID		4300	4175
HPRD ID		01163	03485
Ensembl ID		ENSG00000171843	ENSG00000076003
Uniprot IDs		B7Z755 P42568 Q6MZE2 Q8IVB0	Q14566
PDB IDs		2LM0	2KLQ 2LE8
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Learning Or Memory Cognition Regulation Of Gene Expression Cell Dedifferentiation Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of Ossification Regulation Of Metabolic Process Negative Regulation Of Tooth Mineralization Synaptic Growth At Neuromuscular Junction Regulation Of Transcription, DNA-templated Single-organism Behavior Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Renal Sodium Ion Absorption Learning Notch Signaling Pathway Behavior Collateral Sprouting Renal Sodium Ion Transport Axon Midline Choice Point Recognition Specification Of Axis Polarity G1/S Transition Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Odontogenesis Axon Choice Point Recognition Regulation Of Gastric Acid Secretion Negative Regulation Of Histone H3-K4 Methylation Regulation Of Ossification Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Remodeling Negative Regulation Of Cellular Senescence Histone H2A Monoubiquitination Renal Absorption Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Hematopoietic Stem Cell Differentiation DNA Unwinding Involved In DNA Replication	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication Chromosome Organization Cellular Metabolic Process DNA Conformation Change Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Cellular Response To Stress Regulation Of Nuclear Cell Cycle DNA Replication DNA Replication Checkpoint Cellular Process Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint DNA Recombination Organelle Organization Negative Regulation Of Cell Cycle
Tagcloud ?		af af9 all1 associate brd4 bridging bromodomain coactivators corepressors elongation enabling engage establishes extends fingerprinting initiate interactome links modulators p19 pluripotent preinitiation rar retinoid tefb transcribed transitions unravel unsuspected	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Difference) ?		af af9 all1 associate brd4 bridging bromodomain coactivators corepressors elongation enabling engage establishes extends fingerprinting initiate interactome links modulators p19 pluripotent preinitiation rar retinoid tefb transcribed transitions unravel unsuspected	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Intersection) ?