MLLT3 and CBX8

Number of citations of the paper that reports this interaction (PMID 11439343)
21

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MLLT3	CBX8
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	chromobox homolog 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Elongation Factor Complex Extracellular Vesicular Exosome	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding	Single-stranded RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Methylated Histone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Segment Specification Anterior/posterior Pattern Specification Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Histone Ubiquitination
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AFF1 APP APPBP2 BCOR CBX8 CDK6 EEF1A1 LRIF1 MCM6 PTN RBM48 SGK1	42 interactors: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 HAP1 HIST3H3 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PHC2 PNMA2 RING1 RNF2 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14
Entrez ID		4300	57332
HPRD ID		01163	13006
Ensembl ID		ENSG00000171843
Uniprot IDs		B7Z755 P42568 Q6MZE2 Q8IVB0	Q9HC52
PDB IDs		2LM0	3I91
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Learning Or Memory Cognition Regulation Of Gene Expression Cell Dedifferentiation Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of Ossification Regulation Of Metabolic Process Negative Regulation Of Tooth Mineralization Synaptic Growth At Neuromuscular Junction Regulation Of Transcription, DNA-templated Single-organism Behavior Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Renal Sodium Ion Absorption Learning Notch Signaling Pathway Behavior Collateral Sprouting Renal Sodium Ion Transport Axon Midline Choice Point Recognition Specification Of Axis Polarity G1/S Transition Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Odontogenesis Axon Choice Point Recognition Regulation Of Gastric Acid Secretion Negative Regulation Of Histone H3-K4 Methylation Regulation Of Ossification Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Remodeling Negative Regulation Of Cellular Senescence Histone H2A Monoubiquitination Renal Absorption Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Hematopoietic Stem Cell Differentiation DNA Unwinding Involved In DNA Replication	Transcription, DNA-templated RNA Biosynthetic Process Histone Modification Chromatin Modification Chromosome Organization Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Ubiquitination Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Histone H2A Monoubiquitination Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Histone H2A Ubiquitination Peptidyl-lysine Modification Regulation Of Metabolic Process Histone Monoubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Organelle Organization Histone Acetylation Protein Modification By Small Protein Conjugation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Monoubiquitination Anterior/posterior Pattern Specification Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Segment Specification Cellular Protein Modification Process Cellular Response To Reactive Oxygen Species
Tagcloud ?		af af9 all1 associate brd4 bridging bromodomain coactivators corepressors elongation enabling engage establishes extends fingerprinting initiate interactome links modulators p19 pluripotent preinitiation rar retinoid tefb transcribed transitions unravel unsuspected	aims approaches beings blotting causes chromobox colon conclude cultured express facilitating hct116 homolog igf1 igf1r knockdown leading line overexpression pathogenesis proliferation promote promoting real reports rt silencing unclear western
Tagcloud (Difference) ?		af af9 all1 associate brd4 bridging bromodomain coactivators corepressors elongation enabling engage establishes extends fingerprinting initiate interactome links modulators p19 pluripotent preinitiation rar retinoid tefb transcribed transitions unravel unsuspected	aims approaches beings blotting causes chromobox colon conclude cultured express facilitating hct116 homolog igf1 igf1r knockdown leading line overexpression pathogenesis proliferation promote promoting real reports rt silencing unclear western
Tagcloud (Intersection) ?