PTPN5 and SNX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PTPN5	SNX4
Description		protein tyrosine phosphatase non-receptor type 5	sorting nexin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cell Junction	Cytoplasm Endosome Early Endosome Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex Presynaptic Endosome
	Molecular Function	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Protein Dephosphorylation Signal Transduction	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly
Pathways		Interleukin-37 signaling
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Myopia ( 27182965) Refractive error ( 32231278)	Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder x sex interaction ( 34099189) Urate levels ( 31578528)
Interacting Genes		19 interacting genes: CCNQ CLEC4G CUL5 CXCL9 CYB561D2 ENTPD3 FYN MAPK1 MAPK3 MARCHF5 MOB1A PRKN SLC35B1 SNX4 TERF1 TMEM201 TMEM51 VTI1B ZBTB5	18 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SUPT5H
Entrez ID		84867	8723
HPRD ID		01472	09334
Ensembl ID		ENSG00000110786	ENSG00000114520
Uniprot IDs		B7Z2F8 P54829 Q86TL3	O95219
PDB IDs		2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1 6H8R 8SLS 8SLT 8SLU 9EEX 9EEY 9EEZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Positive Regulation Of Defense Response ERBB2 Signaling Pathway Interleukin-34-mediated Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Organelle Organization Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Defense Response Negative Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamate Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Inflammatory Response Immune Response-activating Signaling Pathway Bergmann Glial Cell Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Immune Response ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Degranulation Activation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Protein K27-linked Ubiquitination Regulation Of Golgi Organization MAP Kinase Activity Pseudopodium Organelle Localization Layer Formation In Cerebral Cortex Response To L-glutamate Positive Regulation Of Macroautophagy Schwann Cell Development Regulation Of Early Endosome To Late Endosome Transport Phospholipase Binding Positive Regulation Of Mitochondrial Fission Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Chromosome Organization Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Protein K48-linked Ubiquitination Face Development Regulation Of Telomere Maintenance	Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Autophagy Receptor Complex Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Protein Tyrosine Kinase Activity Glomerular Capillary Formation Lipid Binding Regulation Of Macroautophagy Platelet-derived Growth Factor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Regulation Of Glucose Metabolic Process Cellular Response To Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Endosome Membrane Membrane Retromer Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Protein Autophosphorylation Response To Growth Factor Adrenal Gland Development Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Myofibril Assembly Negative Regulation Of ERBB Signaling Pathway Cellular Localization Negative Regulation Of Catabolic Process Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Endosome Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Organelle Organization Protein-containing Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Leptin Receptor Activity Platelet-derived Growth Factor Alpha-receptor Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
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