PTCD2 and TRIM32

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTCD2	TRIM32
Description		pentatricopeptide repeat domain 2	tripartite motif containing 32
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Centrosome Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	RNA Binding Protein Binding	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Myosin Binding Protein-macromolecule Adaptor Activity Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Kidney Development Liver Development MRNA Processing Mitochondrion Organization Heart Development Regulation Of Gene Expression Regulation Of MRNA Processing Muscle Cell Development Ventricular Cardiac Muscle Tissue Morphogenesis	Autophagosome Assembly Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Actin Ubiquitination Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Cellular Homeostasis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Viral Transcription Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Tumor Necrosis Factor Response To Starvation Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Cilium Assembly Axon Development Cytosolic Ciliogenesis Protein K63-linked Ubiquitination Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Motility Positive Regulation Of Autophagosome Assembly
Pathways			Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Asthma (childhood onset) ( 31036433) Glaucoma ( 31959993) Intraocular pressure ( 29617998 29785010 30054594 31959993) Pulse pressure ( 27841878) Refractive error ( 32231278)	Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: MID1 MID2 TRIM32 USP49	62 interacting genes: ABI2 ATXN1 BTG3 CFTR CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN4 VPS11 XIAP
Entrez ID		79810	22954
HPRD ID		15193	03797
Ensembl ID		ENSG00000049883	ENSG00000119401
Uniprot IDs		B3KPU6 B7Z8R2 F6S289 Q8WV60	Q13049
PDB IDs			2CT2 5FEY
Enriched GO Terms of Interacting Partners?		Protein Localization To Microtubule Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription Ubiquitin Protein Ligase Activity Phosphoprotein Binding Protein Localization To Cytoskeleton Negative Regulation Of Viral Process Protein Localization To Organelle Zinc Ion Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Regulation Of Viral Process Post-translational Protein Modification Protein Localization To Phagocytic Vesicle Positive Regulation Of Autophagy Striated Muscle Myosin Thick Filament Regulation Of Signal Transduction Actin Modification Histone H2B Deubiquitinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Microtubule Binding Cytosolic Ciliogenesis Regulation Of Cell Communication Regulation Of Signaling Transcription Coactivator Activity Defense Response To Virus Free Ubiquitin Chain Polymerization Metal Ion Binding Regulation Of Canonical NF-kappaB Signal Transduction Microtubule Tat Protein Binding Regulation Of Autophagy Enzyme Binding Positive Regulation Of Signal Transduction Protein Modification Process Response To Virus Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Transferase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cell Communication Intracellular Protein Localization Positive Regulation Of Signaling Identical Protein Binding Translation Initiation Factor Binding Host-mediated Suppression Of Symbiont Invasion	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Cellular Response To Nitrogen Starvation Protein Polyubiquitination Protein Modification Process Phosphatidylethanolamine Binding Ubiquitin-protein Transferase Activity Autophagosome Ubiquitin Protein Ligase Activity Autophagy Protein Metabolic Process Autophagosome Maturation Positive Regulation Of Post-translational Protein Modification Mitophagy Positive Regulation Of Protein Polyubiquitination Protein K63-linked Ubiquitination Autophagy Of Mitochondrion Ubiquitin Protein Ligase Binding Autophagosome Membrane Cellular Response To Nutrient Levels Regulation Of Protein Polyubiquitination Autophagosome Assembly Protein-containing Complex Disassembly Response To Stress Cellular Response To Stress Autophagosome Organization Catabolic Process Positive Regulation Of Protein Ubiquitination Macroautophagy Vacuole Organization Regulation Of Post-translational Protein Modification Protein Binding Macromolecule Metabolic Process Cytoplasmic Vesicle Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Phospholipid Binding Transferase Activity Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Nucleation Positive Regulation Of Protein Metabolic Process Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process Organelle Membrane
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