PTCD2 and USP49

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTCD2	USP49
Description		pentatricopeptide repeat domain 2	ubiquitin specific peptidase 49
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Protein Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity
	Biological Process	Kidney Development Liver Development MRNA Processing Mitochondrion Organization Heart Development Regulation Of Gene Expression Regulation Of MRNA Processing Muscle Cell Development Ventricular Cardiac Muscle Tissue Morphogenesis	MRNA Splicing, Via Spliceosome Chromatin Organization Chromatin Remodeling MRNA Processing Proteolysis RNA Splicing Protein Deubiquitination Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Asthma (childhood onset) ( 31036433) Glaucoma ( 31959993) Intraocular pressure ( 29617998 29785010 30054594 31959993) Pulse pressure ( 27841878) Refractive error ( 32231278)	Cutaneous psoriasis ( 26626624) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 20139978 32888494) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		4 interacting genes: MID1 MID2 TRIM32 USP49	11 interacting genes: H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774
Entrez ID		79810	25862
HPRD ID		15193	10075
Ensembl ID		ENSG00000049883	ENSG00000164663
Uniprot IDs		B3KPU6 B7Z8R2 F6S289 Q8WV60	Q70CQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Localization To Microtubule Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription Ubiquitin Protein Ligase Activity Phosphoprotein Binding Protein Localization To Cytoskeleton Negative Regulation Of Viral Process Protein Localization To Organelle Zinc Ion Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Regulation Of Viral Process Post-translational Protein Modification Protein Localization To Phagocytic Vesicle Positive Regulation Of Autophagy Striated Muscle Myosin Thick Filament Regulation Of Signal Transduction Actin Modification Histone H2B Deubiquitinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Microtubule Binding Cytosolic Ciliogenesis Regulation Of Cell Communication Regulation Of Signaling Transcription Coactivator Activity Defense Response To Virus Free Ubiquitin Chain Polymerization Metal Ion Binding Regulation Of Canonical NF-kappaB Signal Transduction Microtubule Tat Protein Binding Regulation Of Autophagy Enzyme Binding Positive Regulation Of Signal Transduction Protein Modification Process Response To Virus Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Transferase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cell Communication Intracellular Protein Localization Positive Regulation Of Signaling Identical Protein Binding Translation Initiation Factor Binding Host-mediated Suppression Of Symbiont Invasion	Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Activity Protein-containing Complex Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Ubiquitination Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nicotinamide Phosphoribosyltransferase Activity Cyclic-di-GMP Binding STING Complex Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Defense Response Positive Regulation Of Macromolecule Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate 2',3'-cyclic GMP-AMP Binding Post-translational Protein Modification Negative Regulation Of Fermentation
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