TAF6 and AHR

Number of citations: 0 (PubMedID 15641800)
Data Source: BioGRID (pull down)

		TAF6	AHR
Name		TATA-box binding protein associated factor 6	aryl hydrocarbon receptor
Structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Cytosol Protein-containing Complex Transcription Factor TFTC Complex SLIK (SAGA-like) Complex MLL1 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Aryl Hydrocarbon Receptor Complex Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA Repair DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Apoptotic Process Negative Regulation Of Cell Population Proliferation MRNA Transcription By RNA Polymerase II Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Blood Vessel Development Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Apoptotic Process Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance Cellular Response To Molecule Of Bacterial Origin Cellular Response To CAMP Cellular Response To Forskolin Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		None	Omeprazole Mexiletine Nimodipine Flutamide Atorvastatin Leflunomide Ginseng Indirubin-3'-monoxime Resveratrol Quercetin Tapinarof beta-Naphthoflavone Emodin 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine Diosmin Kynurenic Acid Epigallocatechin gallate Cantharidin Indirubin Carbendazim Indigo
GWAS		Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Refractive error ( 32231278 ) Subcortical volume (MOSTest) ( 32665545 )	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Bitter beverage consumption ( 31046077 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Caffeine consumption ( 21490707 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Coffee consumption ( 31046077 25288136 21357676 29367735 31345160 31959922 ) Coffee consumption (cups per day) ( 25288136 31837886 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous squamous cell carcinoma ( 32041948 27424798 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels ( 32203549 ) Inflammatory bowel disease ( 26192919 ) Lung cancer in ever smokers ( 28604730 ) Metabolic traits ( 21886157 ) Microalbuminuria ( 31511532 ) Plasma kynurenine levels in major depressive disorder ( 29317604 ) Rosacea symptom severity ( 29771307 ) Severe influenza A (H1N1) infection ( 26379185 ) Sweet beverage consumption ( 31046077 ) Tea consumption ( 31046077 ) Triglyceride levels ( 32203549 ) Ulcerative colitis ( 26192919 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 31630189 31511532 ) Urinary potassium excretion ( 31409800 ) Urinary sodium excretion ( 31409800 )
Novel Interactors		None recorded	1 novel interactors: GSDME
Interacting Genes		26 interacting genes: AHR APP BANP BTG3 CIITA GTF2E1 H3-4 HNF4A NCOR1 NFYA NFYB NFYC NR1D2 PIH1D2 RELA SH3KBP1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF7 TAF8 TAF9	35 interacting genes: AIP AR ARNT ARNT2 BMAL1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 SRC STUB1 TAF4 TAF6 TAF7 TAF9 TBL3 TBP XPO1
Entrez ID		6878	196
HPRD ID		11807	02596
Ensembl ID		ENSG00000106290	ENSG00000106546
Uniprot IDs		A4D299 P49848	P35869
PDB IDs		5FUR 6F3T 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGH 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	5NJ8 7ZUB 8QMO
GO Terms Enriched among Interactors		Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Transcription Factor TFTC Complex Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Heterodimerization Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleus Protein-containing Complex Assembly Positive Regulation Of Metabolic Process MRNA Metabolic Process Nucleic Acid Metabolic Process Protein-containing Complex Organization CCAAT-binding Factor Complex Regulation Of DNA Repair TBP-class Protein Binding MLL1 Complex Chromatin Regulation Of Gene Expression DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process	Aryl Hydrocarbon Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II General Transcription Initiation Factor Activity MRNA Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Nucleus Nucleic Acid Metabolic Process MRNA Transcription Regulation Of Gene Expression Transcription Preinitiation Complex Assembly Transcription Factor TFIID Complex DNA-binding Transcription Factor Binding Chromatin DNA-templated Transcription Initiation Nuclear Receptor Binding RNA Metabolic Process DNA Binding Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Intracellular Receptor Signaling Pathway Aryl Hydrocarbon Receptor Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coactivator Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II