FBN1 and SECISBP2L

Data Source: HiPPIP (Novel)

		FBN1	SECISBP2L
Name		fibrillin 1	SECIS binding protein 2 like
Structure			No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Mitochondrion Ribonucleoprotein Complex
	Molecular Function	Integrin Binding Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Protein-containing Complex Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding Selenocysteine Insertion Sequence Binding Ribonucleoprotein Complex Binding
	Biological Process	Skeletal System Development Metanephros Development Kidney Development Glucose Metabolic Process Signal Transduction Heart Development Gene Expression Protein Kinase A Signaling Lung Development Positive Regulation Of Appetite Cell Adhesion Mediated By Integrin Activation Of Protein Kinase A Activity Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Negative Regulation Of Osteoclast Differentiation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Lung Alveolus Development Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Osteoclast Development	Selenocysteine Incorporation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	None
Diseases		Geleophysic dysplasia Weill-Marchesani syndrome, including: Weill-Marchesani syndrome; Weill-Marchesani-like syndrome Shprintzen-Goldberg syndrome Ectopia lentis MASS phenotype Marfan syndrome, including: Marfan syndrome (MFS); Neonatal MFS; Atypically severe MFS; New variant of MFS	None
GWAS		Breast cancer ( 17903305 ) Central corneal thickness ( 32528159 29760442 ) Height ( 32499652 31562340 ) Hepcidin/ferritin ratio ( 27846281 ) Hip circumference adjusted for BMI ( 34021172 28552196 ) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160 ) Intraocular pressure ( 29617998 ) Macular thickness ( 30535121 ) Pulse pressure ( 28739976 30578418 27841878 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Refractive error ( 32231278 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Spontaneous coronary artery dissection ( 32374345 ) Systolic blood pressure ( 27841878 30578418 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Thoracic aortic aneurysms and dissections ( 21909107 ) Waist circumference adjusted for body mass index ( 34021172 )	Alcohol consumption (drinks per week) ( 30643258 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung adenocarcinoma ( 28604730 31326317 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Weight ( 28552196 )
Novel Interactors		8 novel interactors: CCPG1 HSCB MYO5C PSMC3 RNF111 SECISBP2L SLBP SPTBN5	1 novel interactors: FBN1
Interacting Genes		18 interacting genes: ATXN7 CALR DCN DYRK1A ELN FBLN2 FBN2 GET4 HGS HOXA1 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SGTB SPRY2 VCAN	2 interacting genes: RNF10 SASH1
Entrez ID		2200	9728
HPRD ID		00618	17181
Ensembl ID		ENSG00000166147	ENSG00000138593
Uniprot IDs		P35555	Q93073
PDB IDs		1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86 5MS9	Not available
GO Terms Enriched among Interactors		Microfibril Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Structural Constituent Conferring Compression Resistance Negative Regulation Of Supramolecular Fiber Organization Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Binding Protein-folding Chaperone Binding Extracellular Region Regulation Of Supramolecular Fiber Organization Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Cytoskeleton Organization Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Eye Morphogenesis Animal Organ Morphogenesis Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Organ Morphogenesis Positive Regulation Of Membrane Depolarization Calcium Ion Binding Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Maintenance Of Location Regulation Of Trophoblast Cell Migration Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Lysosomal Lumen Embryonic Morphogenesis Golgi Lumen Regulation Of Mitochondrial Depolarization Glycosaminoglycan Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Organ Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Fibronectin Binding Protein Targeting To ER Regulation Of Cytoskeleton Organization Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Metabolic Process	Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Sequestering Of BMP In Extracellular Matrix Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Positive Regulation Of Response To Food Sequestering Of TGFbeta In Extracellular Matrix Regulation Of Kinase Activity Regulation Of Multicellular Organismal Development Positive Regulation Of Appetite Negative Regulation Of Osteoclast Development Negative Regulation Of Cell Development Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase A Activity Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Protein Autoubiquitination Post-embryonic Eye Morphogenesis Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Extracellular Negative Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Osteoclast Development Cellular Response To Insulin-like Growth Factor Stimulus Extracellular Matrix Constituent Conferring Elasticity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Protein Kinase A Signaling Positive Regulation Of JUN Kinase Activity Microfibril Regulation Of Protein K63-linked Ubiquitination Regulation Of Developmental Process Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Response To Food Negative Regulation Of Glial Cell Proliferation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Myelination Protein Ubiquitination Regulation Of Protein Modification Process Regulation Of Appetite Negative Regulation Of Cell Differentiation Embryonic Eye Morphogenesis Positive Regulation Of P38MAPK Cascade Regulation Of Multicellular Organismal Process Cell Adhesion Mediated By Integrin