RAB8A and MALT1

		RAB8A	MALT1
Description		RAB8A, member RAS oncogene family	MALT1 paracaspase
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosome Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Membrane Trans-Golgi Network Transport Vesicle Dendrite Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Ciliary Base Non-motile Cilium Glutamatergic Synapse	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding Protein Tyrosine Kinase Binding	Protease Binding Endopeptidase Activity Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Hydrolase Activity Kinase Activator Activity Small Molecule Binding Identical Protein Binding Endopeptidase Activator Activity
	Biological Process	Exocytosis Vesicle Docking Involved In Exocytosis Autophagy Golgi Organization Axonogenesis Regulation Of Autophagy Protein Transport Cell Projection Organization Endocytic Recycling Cellular Response To Insulin Stimulus Regulation Of Protein Localization Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	B-1 B Cell Differentiation Immune System Process Positive Regulation Of Immune Effector Process Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Proteolysis Defense Response Response To Fungus Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Nuclear Export Positive Regulation Of Multicellular Organismal Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper 17 Cell Differentiation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494)	Metabolite levels ( 23823483) Multiple sclerosis ( 21833088 31604244)
Interacting Genes		23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC	15 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2
Entrez ID		4218	10892
HPRD ID		01296	06892
Ensembl ID		ENSG00000167461	ENSG00000172175
Uniprot IDs		P61006	A8K5S1 Q9UDY8
PDB IDs		3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6WHE 6YX5 6ZSI 6ZSJ 7BWT 7LWB 9IKQ	2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9 7A41 7AK0 7AK1 7PAV 7PAW 8CZO 8J5I 8V4X
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Establishment Of Protein Localization Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Localization Cytoplasmic Vesicle Golgi To Plasma Membrane Transport Secretion By Cell Endosome Trans-Golgi Network Recycling Endosome Membrane Secretion Polyubiquitin Modification-dependent Protein Binding Spontaneous Neurotransmitter Secretion Intracellular Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Intracellular Signal Transduction Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Positive Regulation Of Protein Localization Golgi Vesicle Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytosol Membrane Interleukin-2-mediated Signaling Pathway Spindle Pole Organelle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Neurexin Family Protein Binding Signal Transduction Organelle Localization By Membrane Tethering Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Positive Regulation Of Protein Export From Nucleus Membrane Docking Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization To Membrane Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Cilium Assembly Regulation Of Cell Projection Assembly K63-linked Polyubiquitin Modification-dependent Protein Binding Establishment Of Vesicle Localization	Protein K63-linked Ubiquitination Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of Protein Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleoplasm Positive Regulation Of Post-translational Protein Modification Ubiquitin Protein Ligase Binding Protein Modification Process Positive Regulation Of Protein Modification Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Modification Process Histone H3R2 Methyltransferase Activity UBC13-MMS2 Complex Histone Arginine N-methyltransferase Activity Ubiquitin Ligase Complex Positive Regulation Of DNA-binding Transcription Factor Activity Histone Methyltransferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Cellular Response To Stress T-helper 1 Type Immune Response CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein-macromolecule Adaptor Activity Protein-containing Complex CD40 Receptor Complex Protein Kinase B Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Regulation Of DNA Repair Positive Regulation Of JUN Kinase Activity
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