DUSP19 and ALK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP19	ALK
Description		dual specificity phosphatase 19	ALK receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Cytoplasm	Plasma Membrane Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity JUN Kinase Phosphatase Activity Hydrolase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity Identical Protein Binding
	Biological Process	MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade	Response To Stress Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Phosphorylation Hippocampus Development Adult Behavior Swimming Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development
Pathways			Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling
Drugs			ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases			Non-small cell lung cancer
GWAS			Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)
Interacting Genes		19 interacting genes: ACTB ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2	19 interacting genes: APBB1 DUSP19 ERBB2 HES1 IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PPM1A PTN PTPN11 PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1
Entrez ID		142679	238
HPRD ID		13254	00104
Ensembl ID		ENSG00000162999	ENSG00000171094
Uniprot IDs		Q8WTR2	A0A0K2YUJ3 B6D4Y2 Q9UM73
PDB IDs		3S4E 4D3P 4D3Q 4D3R	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7BTT 7JY4 7JYR 7JYS 7JYT 7LRZ 7LS0 7MZW 7MZY 7N00 7NWZ 7NX3 7NX4 7R7K 7R7R 8ARJ 9G5I 9GBE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Receptor Complex Nucleotide Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Protein Autophosphorylation Protein Phosphorylation Phosphorylation Positive Regulation Of Signal Transduction Growth Factor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Coreceptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Signal Transduction Response To Growth Factor Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Axon Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Positive Regulation Of Phosphate Metabolic Process ERBB3:ERBB2 Complex ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade	Regulation Of Apoptotic Process Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Negative Regulation Of Apoptotic Process ERBB Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cell Adhesion Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Hemopoiesis Negative Regulation Of T Cell Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Receptor Tyrosine Kinase Binding Leukocyte Activation Positive Regulation Of Gliogenesis Intracellular Signal Transduction Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Glial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Immune System Process Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Negative Regulation Of Lymphocyte Activation Lymphocyte Activation Cell Activation Response To Growth Factor Negative Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Leukocyte Activation Insulin-like Growth Factor Receptor Signaling Pathway
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