DUSP19 and EPHB6

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP19	EPHB6
Description		dual specificity phosphatase 19	EPH receptor B6
Image
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity JUN Kinase Phosphatase Activity Hydrolase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Ephrin Receptor Signaling Pathway
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Cancer ( 29299148)
Interacting Genes		19 interacting genes: ACTB ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2	28 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39 VPS26C
Entrez ID		142679	2051
HPRD ID		13254	04133
Ensembl ID		ENSG00000162999	ENSG00000106123
Uniprot IDs		Q8WTR2	A0A0G2JNH7 F8WCM8 O15197
PDB IDs		3S4E 4D3P 4D3Q 4D3R	7K7J
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Receptor Complex Nucleotide Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Protein Autophosphorylation Protein Phosphorylation Phosphorylation Positive Regulation Of Signal Transduction Growth Factor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Coreceptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Signal Transduction Response To Growth Factor Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Axon Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Positive Regulation Of Phosphate Metabolic Process ERBB3:ERBB2 Complex ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade	Ephrin Receptor Binding Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Helper T Cell Diapedesis Cerebellar Neuron Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Inhibitor Activity Cellular Response To Growth Factor Stimulus Ephrin Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Response To Growth Factor Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Cerebral Cortex Development Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Schwann Cell Development Protein Tyrosine/serine/threonine Phosphatase Activity Establishment Of Cell Polarity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization SH3 Domain Binding Neuron Projection Development Regulation Of Protein Serine/threonine Kinase Activity Cytoplasm Signal Transduction Protein Binding Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Rac Protein Signal Transduction T Cell Migration Identical Protein Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Spermidine Binding
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