RCAN1 and PPP3R1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		RCAN1	PPP3R1
Description		regulator of calcineurin 1	protein phosphatase 3 regulatory subunit B, alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Membrane Sarcolemma Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding Protein Phosphatase Inhibitor Activity Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Identical Protein Binding	Phosphoprotein Phosphatase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Response To Ischemia Response To Stress Response To Oxidative Stress Skeletal Muscle Tissue Development Short-term Memory Response To Mechanical Stimulus Calcium-mediated Signaling Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Estrogen Skeletal Muscle Fiber Development Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Protein Import Into Nucleus Heart Development Schwann Cell Development Myelination In Peripheral Nervous System Calcineurin-NFAT Signaling Cascade Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Lung Epithelial Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways			Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Dipyridamole	Myristic acid Voclosporin
Diseases
GWAS		Cancer ( 29299148) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	General cognitive ability ( 29844566) Height ( 25282103) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)
Interacting Genes		22 interacting genes: APP BTRC CXXC5 E2F3 GSK3B MAP3K3 MAPK3 NEUROD2 PICK1 PPP3CA PPP3CB PPP3R1 PRDM4 PTPRD SF3A2 SOX10 SOX9 SPARCL1 USP22 UXT ZNF292 ZNF350	12 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 MYC NAP1L2 NFATC1 NFATC2 PPP3CA PPP3CC RCAN1
Entrez ID		1827	5534
HPRD ID		04226	03195
Ensembl ID		ENSG00000159200	ENSG00000221823
Uniprot IDs		B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9	P63098
PDB IDs		6UUQ	1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU 7U0T 9B9G 9CHU 9CHV 9CHX
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Regulation Of Transcription By RNA Polymerase II Glial Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Protein Serine/threonine Phosphatase Complex Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Glutamatergic Synapse Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Signaling Cassette Cell Development Regulation Of Endocytosis Positive Regulation Of Calcium Ion Import Protein Dimerization Activity Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Monoatomic Ion Transport Regulation Of Vesicle-mediated Transport Calmodulin-dependent Protein Phosphatase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport	Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Intracellular Signaling Cassette Myotube Cell Development Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Smooth Muscle Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Calcium Channel Regulator Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Signal Transduction Striated Muscle Cell Development Negative Regulation Of Muscle Cell Differentiation Protein Serine/threonine Phosphatase Complex Positive Regulation Of Kidney Development Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Muscle Cell Development Regulation Of Calcium-mediated Signaling Regulation Of Cell Differentiation Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cell Differentiation Regulation Of Developmental Process Intracellular Signal Transduction Positive Regulation Of Calcium Ion Import Skeletal Muscle Fiber Development Regulation Of Muscle Cell Differentiation Regulation Of Kidney Development Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Developmental Process Regulation Of Calcium Ion Import Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Negative Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Calcium Ion Transport Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Axonemal Basal Plate Positive Regulation Of Calcium-mediated Signaling Calcium Ion Binding Positive Regulation Of Calcium Ion Transmembrane Transport Response To Ischemia Excitatory Postsynaptic Potential Negative Regulation Of Cation Transmembrane Transport
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