TRMO and PMS2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TRMO	PMS2
Description		tRNA methyltransferase O	PMS1 homolog 2, mismatch repair system component
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytosol Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity	Nucleotide Binding DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Mismatched DNA Binding Single Base Insertion Or Deletion Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	TRNA Processing TRNA Methylation Methylation	DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes
Pathways			Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Orofacial clefts ( 33137956)
Interacting Genes		22 interacting genes: AURKA BCL10 BMPR1A BUB1 CCND1 DCC DLC1 EGFR ERBB2 MCC MLH1 NRAS PMS2 PTEN PTPRJ RAD54B RB1 SMAD2 SPATC1L STAC STK11 TGFBR2	18 interacting genes: AKT1 ANP32B CCDC180 CRYAA EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC VPS26C XPA ZNF189
Entrez ID		51531	5395
HPRD ID		12945	02598
Ensembl ID		ENSG00000136932	ENSG00000122512
Uniprot IDs		Q5T114 Q9BU70	A0A2R8Y6S3 A0A8V8TNX6 A0A8V8TNY8 A0A8V8TP61 A0A8V8TP84 A0A8V8TPE1 A0A8V8TQ50 A0A8V8TQ92 A0A8V8TQG9 A0A8V8TQI1 A0A8V8TQS5 B4DGM0 C9J167 P54278
PDB IDs			1EA6 1H7S 1H7U 5U5R 6MFQ 7RCB 7RCI 7RCK
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Proliferation Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Kinase Activity Regulation Of Cell Population Proliferation Signal Transduction Regulation Of Growth Kinase Activity Heart Valve Morphogenesis Regulation Of Phosphorylation Regulation Of Cell Differentiation Heart Development Negative Regulation Of Developmental Process Negative Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cell Population Proliferation Regulation Of Signal Transduction Endocardial Cushion Morphogenesis Nucleotide Binding Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Development Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process MutLalpha Complex Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Phosphorylation Ruffle Membrane Negative Regulation Of Growth Apoptotic Process Regulation Of Cell Growth Tricuspid Valve Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Programmed Cell Death Cytosol Cell Death Aortic Valve Morphogenesis Regulation Of Cell Cycle Phase Transition Mismatch Repair Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Cycle Process	Response To Oxidative Stress Positive Regulation Of Deoxyribonuclease Activity Mismatch Repair Response To UV Response To UV-A Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Hydrogen Peroxide DNA Repair Response To Light Stimulus Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Stress Enzyme Binding TRNA Methylation Nucleus Regulation Of TRNA Methylation Response To Radiation Response To Reactive Oxygen Species DNA Metabolic Process DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Late Recombination Nodule Somatic Diversification Of Immunoglobulins Meiotic Metaphase I Homologous Chromosome Alignment PCNA Complex Replisome Negative Regulation Of Sodium-dependent Phosphate Transport Nucleotide-excision Repair, DNA Damage Recognition Double-stranded DNA 5'-3' DNA Exonuclease Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity Male Germ Cell Nucleus Nucleotide-excision Repair
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