TRMO and STAC

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		TRMO	STAC
Description		tRNA methyltransferase O	SH3 and cysteine rich domain
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane T-tubule Sarcolemma
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	TRNA Processing TRNA Methylation Methylation	Skeletal Muscle Contraction Muscle Contraction Signal Transduction Cellular Response To Heat Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cation Channel Activity
Pathways
Drugs
Diseases
GWAS		Orofacial clefts ( 33137956)	Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 29273806) Brooding (response to stress) ( 30886212) Celiac disease ( 23936387) Erectile dysfunction in type 1 diabetes ( 22704111) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 31537649) Metabolite levels ( 23823483) Smoking behaviour (maximum cigarettes in a 24 hour period) ( 29532581)
Interacting Genes		22 interacting genes: AURKA BCL10 BMPR1A BUB1 CCND1 DCC DLC1 EGFR ERBB2 MCC MLH1 NRAS PMS2 PTEN PTPRJ RAD54B RB1 SMAD2 SPATC1L STAC STK11 TGFBR2	22 interacting genes: APP FBXO25 GOLGA2 KANK2 KIAA1958 LIMD1 LMNA LRRK2 LZTS2 MEOX2 NBPF19 NCKIPSD NEDD4L NOTCH2NLA PAX5 PAX6 PJA1 POU6F2 RNF208 STAT5B TRIP6 TRMO
Entrez ID		51531	6769
HPRD ID		12945	11890
Ensembl ID		ENSG00000136932	ENSG00000144681
Uniprot IDs		Q5T114 Q9BU70	B4DR96 B4DZ13 E9PEA7 Q8WUK8 Q99469
PDB IDs			2DL4 6B25
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Proliferation Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Kinase Activity Regulation Of Cell Population Proliferation Signal Transduction Regulation Of Growth Kinase Activity Heart Valve Morphogenesis Regulation Of Phosphorylation Regulation Of Cell Differentiation Heart Development Negative Regulation Of Developmental Process Negative Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cell Population Proliferation Regulation Of Signal Transduction Endocardial Cushion Morphogenesis Nucleotide Binding Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Development Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process MutLalpha Complex Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Phosphorylation Ruffle Membrane Negative Regulation Of Growth Apoptotic Process Regulation Of Cell Growth Tricuspid Valve Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Programmed Cell Death Cytosol Cell Death Aortic Valve Morphogenesis Regulation Of Cell Cycle Phase Transition Mismatch Repair Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Cycle Process	Cellular Response To Manganese Ion
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