SRPK2 and BUD13

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		SRPK2	BUD13
Description		SRSF protein kinase 2	BUD13 spliceosome associated protein
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nuclear Speck Presynapse	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP RES Complex U2-type Precatalytic Spliceosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity 14-3-3 Protein Binding Protein Serine Kinase Activity	RNA Binding Protein Binding
	Biological Process	Spliceosomal Complex Assembly Angiogenesis MRNA Processing Protein Phosphorylation Positive Regulation Of Cell Population Proliferation RNA Splicing Regulation Of Gene Expression Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing R-loop Processing	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly
Pathways		Maturation of nucleoprotein	mRNA Splicing - Major Pathway
Drugs		Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 34002096 31043756) General cognitive ability ( 29844566) Myopia (pathological) ( 23049088) Regular attendance at a religious group ( 29970889) Schizophrenia ( 29483656 30285260 28991256 25056061) Uterine fibroid size (maximum dimension) ( 30196971) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Youthful appearance (self-reported) ( 32339537)	Adventurousness ( 30643258) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Cardiovascular risk factors (age interaction) ( 20838585) Coronary artery disease ( 29263402 29212778) Cutaneous squamous cell carcinoma ( 32041948 27424798) Delirium ( 29631748) Disease progression in age-related macular degeneration ( 29346644) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HIV-1 susceptibility ( 21160409) Hypertriglyceridemia ( 23505323 31087446) LDL cholesterol ( 20864672) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid traits ( 24023261) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Low density lipoprotein cholesterol levels ( 33339817) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolic syndrome ( 21386085 30382898) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23823483 31628463) Platelet count ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Red cell distribution width ( 28957414) Response to Vitamin E supplementation ( 22437554) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716 29615537 32902719 32203549 28371326 26763881 30911093) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 20864672 26160806 24886709 18193044 21909109) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)
Interacting Genes		416 interacting genes: ABL1 ACIN1 ACTB ACTG1 ADAMTS18 ADGRG5 ADPRH AHCYL1 AKAP13 AKT1 ALDOA ALKBH3 ALPL AMER1 AMMECR1L ANK3 ANKFY1 ANKRD35 AP1M1 APEX1 APOBEC3C APP ARFGEF3 ARGLU1 ARHGAP12 ARK2N ARL6IP4 ARPC1B ARSG ASL ATAT1 AURKA BAG3 BAIAP2 BAZ1A BCL9L BCLAF1 BTG3 BUD13 C16orf78 C1orf35 C4orf46 CACNG2 CADPS2 CALCOCO1 CAMSAP1 CAND1 CARD11 CARHSP1 CASK CBLN4 CCDC28A CCDC86 CCDC88B CCDC97 CCM2 CDC42EP4 CDK12 CDK13 CDK7 CEP170 CHD1L CHD2 CHEK2 CHERP CHTOP CHUK CLASP1 CLASP2 CLASRP CLCNKA CLDN19 CLK1 CLK2 CLK3 CLU COIL CPLANE1 CPSF7 CRTC1 CSAG1 CTNNBL1 DAW1 DBF4B DCAF10 DDX39B DDX3X DDX46 DDX50 DDX6 DHX8 DIDO1 DNAH6 DNAH9 DNAJC8 DOCK3 DRAP1 DRG1 DYRK1A ECT2 EED EFCAB12 EGLN2 EIF1AY EIF3A EIF4B EIF4G1 ELAVL3 ELP6 ENOX2 ENSA EPB41L1 EPB41L4A EPB41L4B EPM2A EPS8L1 EPS8L3 ERBB3 ERC1 ERCC3 ERN1 EVI5L EXOSC8 F5 FAM43A FAM76B FAM90A1 FBXO24 FCHO1 FGF12 FGFR3 FIP1L1 FMNL1 FOXN3 FXR1 FXR2 GABARAP GABARAPL1 GBF1 GCC2 GGCX GHR GLRA4 GNGT2 GSE1 GTF2E1 GTPBP4 GXYLT2 H2BC12 HBS1L HERC3 HIRIP3 HIVEP1 HMCN2 HMGA1 HMGN2 HMGN3 HMGXB4 HNRNPA1 HNRNPA3 HNRNPC HNRNPK HOMER3 HOXB6 HTATSF1 IFIT5 IRS2 ISLR JMJD1C KANK2 KCNN2 KHDRBS1 KIF11 KRT78 LBR LCA5 LCE3D LDHA LDHC LGMN LINC00322 LMNA LMNB1 LMO7 LRRC34 LRRC52 LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MACF1 MACO1 MAGEB1 MAP1S MAP3K20 MAP4 MAP7 MAP7D1 MAPKAPK3 MAPKAPK5 MAPRE1 MAPT MARCHF10 MAST2 MATR3 MCOLN3 MDC1 MDK MIB2 MIPOL1 MMP23B MPP3 MRPS6 MSI2 MTCL1 MYCBP2 MYLIP MYO18B MYO1E MZT2B NADK NAGK NCBP3 NCK2 NCL NELFE NGDN NGLY1 NKAP NOLC1 NOM1 NOP16 NOP53 NPM2 NSMCE4A NSRP1 NSUN5P2 NTHL1 NUP50 NXF1 NXPE4 NXT2 OBI1 OCEL1 OTOF PABPC4 PAK4 PALLD PCBP1 PCF11 PDCL3 PDE7B PELI1 PHF6 PHLDB1 PKD1L2 PLEKHA5 PNISR PNMA8B POLB POLDIP3 PPHLN1 PPIA PPIL1 PPP1R13L PRKAA1 PRP4K PRPF38A PRPF38B PRPF40A PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2A PRRC2B PRRC2C PSMA3 PSMD13 PTBP1 PTBP2 PTPN22 RABEP1 RASGRF1 RBM15 RBM15B RBM19 RBM8A RBMX RIPK3 RIT1 RIT2 RNF4 RPL13 RPL22 RPL34 RPL37 RPL39L RPL41 RPLP2 RPS26 RRM2B RRP1 RRP1B RSRC1 RSRC2 RSRP1 RTF1 RWDD2B RXFP1 S100A4 SAFB SART1 SBK1 SCAF1 SDK2 SDR42E1 SEC16B SEC23B SELENOS SERPING1 SGPL1 SIPA1L3 SLAIN2 SLC13A2 SLC17A6 SLC75A1 SLFN5 SLTM SMCHD1 SNIP1 SNRNP27 SNRNP35 SNURF SPDEF SPEN SRC SREK1 SRI SRRM1 SRRM2 SRSF1 SRSF11 SRSF12 SRSF3 SRSF7 SRSF8 SRSF9 SRXN1 STON1 SUPT16H SYCP2 TAF7L TCEANC2 TCOF1 TDP2 TLE4 TLE5 TMPO TMPRSS11A TMSB10 TNFAIP8L2 TNFRSF10C TNIP2 TNS3 TOGARAM1 TOP1 TPD52 TRIM41 TRIP12 TTN TUBA1B TXN U2AF1 U2AF2 UBD UBE2E2 UBR4 UNKL UPF3B USP39 VAC14 VAV2 VRK1 VSTM2L WDR24 WDR5 WDR70 XRCC5 YBX3 YPEL2 YPEL3 YRDC YTHDC1 YTHDC2 ZC3H13 ZCCHC17 ZDHHC5 ZFC3H1 ZFHX4 ZFP91 ZMAT4 ZMYM4 ZNF140 ZNF234 ZNF529 ZNF592 ZNF593 ZNF616 ZRANB2 ZRSR2 ZSCAN12 ZSCAN9	3 interacting genes: GPKOW RBMX2 SRPK2
Entrez ID		6733	84811
HPRD ID		04280	11307
Ensembl ID		ENSG00000135250	ENSG00000137656
Uniprot IDs		A0A994J591 C9J2M4 P78362	Q9BRD0
PDB IDs		2X7G 5MYV 7ZKX	5Z56 5Z57 5Z58 6FF4 6FF7 7ABI 7DVQ 7QTT 8CH6 8I0P 8I0R
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Processing RNA Splicing MRNA Binding MRNA Metabolic Process Nucleic Acid Binding RNA Processing Nucleus Nuclear Speck RNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Processing Spliceosomal Complex Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Splicing Protein-RNA Complex Assembly Macromolecule Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Catalytic Step 2 Spliceosome RNA Transport Negative Regulation Of MRNA Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Post-transcriptional Regulation Of Gene Expression MRNA Splice Site Recognition Spliceosomal Complex Assembly Ribonucleoprotein Complex Regulation Of Gene Expression Nucleolus Nucleobase-containing Compound Transport Regulation Of Microtubule Polymerization RNA Export From Nucleus RS Domain Binding MRNA Export From Nucleus Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Translation Microtubule Cortical Microtubule Cytoskeleton Negative Regulation Of Gene Expression	RNA Splicing Spliceosomal Complex Assembly MRNA Processing MRNA Metabolic Process RNA Processing Protein-RNA Complex Assembly Nuclear Speck Organization MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Negative Regulation Of RIG-I Signaling Pathway RNA Metabolic Process R-loop Processing RNA Binding Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Nuclear Body Organization Precatalytic Spliceosome Regulation Of RIG-I Signaling Pathway Nucleic Acid Metabolic Process Nucleic Acid Binding U2-type Prespliceosome Assembly U2 SnRNP
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