SRPK2 and RPL41

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		SRPK2	RPL41
Gene Name		SRSF protein kinase 2	ribosomal protein L41
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Cytosol Cytosolic Large Ribosomal Subunit
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding 14-3-3 Protein Binding	RNA Binding Structural Constituent Of Ribosome
	Biological Process	Spliceosomal Complex Assembly Angiogenesis Protein Phosphorylation Positive Regulation Of Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088)	Systemic sclerosis ( 21779181)
Protein-Protein Interactions		177 interactors: ABL1 ACIN1 ADPRH AES AHCYL1 ALKBH3 AMMECR1L APEX1 APOBEC3C APP ARGLU1 ARHGAP12 ARL6IP4 ARPC1B ATAT1 AURKA BAIAP2 BRD3 C16orf78 C17orf85 C18orf25 C1orf35 C4orf46 CACNG2 CAND1 CASK CBLN4 CBX5 CCDC28A CCDC97 CCM2 CDC42EP4 CDK7 CHD2 CHERP CHTOP CHUK CLDN19 CLK1 CLK2 CLK3 CSAG1 CTNNBL1 DAW1 DBF4B DDX21 DDX46 DDX6 DHX8 DNAJC8 DRAP1 DRG1 EGLN2 EIF1AY ENOX2 EPB41L1 EPB41L4A EPS8L3 ERCC3 ERN1 EVI5L FAM76B FAM90A1 FGF12 FOXN3 FXR2 GABARAP GABARAPL1 GPR114 GTF2E1 HBS1L HIRIP3 HMGN3 HNRNPC HOMER3 IFIT5 KCNN2 LCA5 LCE3D LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MAGEB1 MAPKAPK5 MARCH10 MCOLN3 MDK MPP3 MRPS6 NCK2 NELFE NGLY1 NOP16 NPM2 NSMCE4A NSRP1 NUP50 NXT2 OCEL1 PABPC4 PAK4 PDE7B PELI1 POLB PPIA PPIL1 PRKAA1 PRPF38A PRPF40A PSMA3 PTBP1 RBM15 RBM23 RBM39 RBM8A RIT1 RIT2 RNF4 RNPS1 RPL22 RPL39L RPL41 RSRC1 RSRC2 RSRP1 RTF1 RWDD2B SDR42E1 SEC23B SLAIN2 SNIP1 SNRNP27 SNRNP35 SNRNP70 SNURF SREK1 SRI SRRM1 SRSF1 SRSF12 SRSF3 SRSF5 SRSF7 SRSF8 SRSF9 STON1 SUPT16H TAF7L TCOF1 TDP2 TLE4 TNFRSF10C TNIP2 TPD52 TRA2A TRA2B TRIM41 TTN U2AF1 U2AF2 UBD UBE2E2 VAV2 VIMP VRK1 WDR5 YPEL2 YPEL3 YTHDC1 YWHAB ZMAT4 ZRANB2 ZRSR2 ZSCAN9	7 interactors: APP CSNK2B IKBKG MAPK14 NUPR1 PRNP SRPK2
Entrez ID		6733	6171
HPRD ID		04280	17999
Ensembl ID		ENSG00000135250	ENSG00000229117
Uniprot IDs		P78362	P62945
PDB IDs		2X7G	3J3B
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing DNA-templated Transcription, Termination Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing MRNA Export From Nucleus MRNA Transport RNA Export From Nucleus RNA 3'-end Processing RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Nuclear Export MRNA Splice Site Selection Negative Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Cellular Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Ribonucleoprotein Complex Assembly Transcription, DNA-templated Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Intracellular Transport Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Defense Response Cellular Copper Ion Homeostasis Chemotaxis Copper Ion Homeostasis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Response To External Stimulus Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Cellular Component Assembly Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway Cell Death Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cell Morphogenesis Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Axon Guidance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway System Development MyD88-dependent Toll-like Receptor Signaling Pathway Anatomical Structure Morphogenesis Toll-like Receptor 4 Signaling Pathway Locomotion Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Growth Protein Phosphorylation
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww	11th anxa2 balb blastn differentially enriched euthanized infected inoculated inoculation messenger myeloma nktr parasite perform putative ranged rbbp4 sequenced sizes sp2 spiralis ssh subcutaneously subtractive trichinella twenty utilized weights
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww	11th anxa2 balb blastn differentially enriched euthanized infected inoculated inoculation messenger myeloma nktr parasite perform putative ranged rbbp4 sequenced sizes sp2 spiralis ssh subcutaneously subtractive trichinella twenty utilized weights
Tagcloud (Intersection) ?