CPLX4 and MGAM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CPLX4	MGAM
Description		complexin 4	maltase-glucoamylase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane SNARE Complex Terminal Bouton Synapse	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	SNARE Binding Protein Binding Syntaxin Binding	Catalytic Activity Glucan 1,4-alpha-glucosidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Oligo-1,6-glucosidase Activity Protein Binding Amylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Alpha-glucosidase Activity
	Biological Process	Neurotransmitter Transport Exocytosis Visual Perception Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission	Maltose Catabolic Process Carbohydrate Metabolic Process Starch Catabolic Process Disaccharide Catabolic Process Dextrin Catabolic Process
Pathways			Digestion of dietary carbohydrate Neutrophil degranulation
Drugs			Acarbose Miglitol Voglibose
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321)	1,5-anhydroglucitol levels ( 28588231) Anorexia nervosa ( 23568457) Idiopathic dilated cardiomyopathy ( 29495422)
Interacting Genes		100 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 APOD AQP1 AQP9 ASGR1 ATP6V0C BMP10 BNIP2 C14orf180 C1GALT1 C3orf52 C5 CACNG1 CCL4L2 CD81 CDIPT CDS2 CLDND2 CLEC4G CLN6 CMTM5 CNIH1 CTSA CTXN3 CYB5B CYBC1 CYP4F2 DEFB127 EMD GAD2 GIMAP1 GRM2 HACD1 HHATL HMOX1 IGFBP5 INSIG2 LHFPL5 LPAR3 MAL MALL MAN2B2 MGAM NINJ2 NRM ORMDL1 PGAP2 PLN PLP2 PLPP4 PNLIPRP1 PTPN9 RTP2 SEC22B SELENOK SFTPC SLC30A2 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC38A7 SLC39A9 SMCO4 SMIM1 SNCA STX3 STX8 SYNJ2BP TF TMEM107 TMEM120B TMEM128 TMEM14A TMEM14B TMEM19 TMEM201 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM267 TMEM42 TMEM60 TMEM79 TMEM86A TMEM97 TRAF3IP3 TSPO2 UBIAD1 VAMP4 VAMP5 VKORC1 WFDC2 YIPF6 ZFPL1	7 interacting genes: AQP6 CPLX4 CREB3L1 GPR42 NCF1 SLC18A1 TMEM14B
Entrez ID		339302	8972
HPRD ID		13091	01104
Ensembl ID		ENSG00000166569	ENSG00000257335
Uniprot IDs		Q7Z7G2	O43451
PDB IDs			2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Golgi Membrane Cholesterol Binding Intracellular Chemical Homeostasis Monoatomic Cation Homeostasis Pyrimidine Nucleotide-sugar Transmembrane Transport Monoatomic Ion Homeostasis Nucleotide-sugar Transmembrane Transport Homeostatic Process Vitamin K Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Golgi Apparatus Spindle Pole Centrosome Cellular Homeostasis Hydrogen Peroxide Channel Activity Negative Regulation Of Chaperone-mediated Autophagy Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Hydrogen Peroxide Transmembrane Transport Nuclear Inner Membrane Respiratory Burst After Phagocytosis Regulation Of Chemokine Production Negative Regulation Of Lipoprotein Metabolic Process Cellular Response To CAMP Zinc:proton Antiporter Activity Zinc Ion Transmembrane Transporter Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Zinc Ion Transmembrane Transport Menaquinone Metabolic Process Lysosome Zinc Ion Transport Glycerol Transmembrane Transport Multicellular Organismal-level Chemical Homeostasis Intracellular Zinc Ion Homeostasis Positive Regulation Of Chemokine Production Cortical Endoplasmic Reticulum Regulation Of Chaperone-mediated Autophagy Endomembrane System Long-chain Fatty Acid Catabolic Process Regulation Of Cellular Localization	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Vesicle-mediated Transport In Synapse Erythrocyte Apoptotic Process Neurotransmitter Transport Terminal Bouton Aminergic Neurotransmitter Loading Into Synaptic Vesicle Neutrophil-mediated Killing Of Fungus Monoatomic Anion Channel Activity Carbon Dioxide Transmembrane Transporter Activity Ammonium Transmembrane Transport Ammonium Channel Activity Renal Water Transport Carbon Dioxide Transmembrane Transport Thioesterase Binding Positive Regulation Of Keratinocyte Migration Presynapse Maintenance Of Postsynaptic Specialization Structure Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Protein Localization To Cleavage Furrow Positive Regulation Of Focal Adhesion Disassembly Cellular Response To Bacterial Lipopeptide Maintenance Of Postsynaptic Density Structure Monoamine:proton Antiporter Activity Serotonin Uptake Amine Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Serotonin:sodium:chloride Symporter Activity Catecholamine Uptake Dopamine Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Norepinephrine Uptake Neurotransmitter Loading Into Synaptic Vesicle Extracellular Matrix Constituent Secretion Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Bacterium Respiratory Burst Involved In Defense Response Phagolysosome Hydrogen Peroxide Biosynthetic Process Cellular Response To Testosterone Stimulus Superoxide-generating NAD(P)H Oxidase Activity Regulation Of Respiratory Burst Involved In Inflammatory Response Superoxide-generating NADPH Oxidase Activator Activity
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