MAGEA2 and P4HA3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MAGEA2	P4HA3
Name		MAGE family member A2	prolyl 4-hydroxylase subunit alpha 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus PML Body	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction By P53 Class Mediator Cellular Senescence Negative Regulation Of Protein Acetylation	Collagen Fibril Organization
Pathways		None	Collagen biosynthesis and modifying enzymes
GWAS		No GWAS studies recorded	Hippocampal atrophy ( 25625606 )
Novel Interactors		1 novel interactors: IRAK1	None recorded
Interacting Genes		21 interacting genes: ACSM1 ANKRD45 BEX1 BEX2 CCDC185 CEP57 COQ4 COX7C DYNLRB1 MBD3 MDM2 NTAQ1 P4HA3 PHKG2 POLL PSMC1 SEPTIN5 SMARCD1 TNIP3 TP53 TRIM28	49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A
Entrez ID		4101	283208
HPRD ID		02165	16413
Ensembl ID		ENSG00000268606	ENSG00000149380
Uniprot IDs		P43356	Q7Z4N8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Antibiotic Response To UV-C Protein-containing Complex SUMO Transferase Activity	Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding