P4HA3 and MAGEA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		P4HA3	MAGEA2
Description		prolyl 4-hydroxylase subunit alpha 3	MAGE family member A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleus PML Body
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity	Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Collagen Fibril Organization	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction By P53 Class Mediator Cellular Senescence Negative Regulation Of Protein Acetylation
Pathways		Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Hippocampal atrophy ( 25625606)
Interacting Genes		49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A	21 interacting genes: ACSM1 ANKRD45 BEX1 BEX2 CCDC185 CEP57 COQ4 COX7C DYNLRB1 MBD3 MDM2 NTAQ1 P4HA3 PHKG2 POLL PSMC1 SEPTIN5 SMARCD1 TNIP3 TP53 TRIM28
Entrez ID		283208	4101
HPRD ID		16413	02165
Ensembl ID		ENSG00000149380	ENSG00000268606
Uniprot IDs		Q7Z4N8	P43356
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding	Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Antibiotic Response To UV-C Protein-containing Complex SUMO Transferase Activity
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