MAGEA2 and COQ4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MAGEA2	COQ4
Name		MAGE family member A2	coenzyme Q4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus PML Body	Mitochondrion Mitochondrial Inner Membrane Membrane Extrinsic Component Of Mitochondrial Inner Membrane Protein-containing Complex Ubiquinone Biosynthesis Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	Protein Binding Lyase Activity 4-hydroxy-3-methoxy-5-polyprenylbenzoate Decarboxylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction By P53 Class Mediator Cellular Senescence Negative Regulation Of Protein Acetylation	Ubiquinone Biosynthetic Process
Pathways		None	Ubiquinol biosynthesis
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Obesity-related traits ( 23251661 )
Interacting Genes		21 interacting genes: ACSM1 ANKRD45 BEX1 BEX2 CCDC185 CEP57 COQ4 COX7C DYNLRB1 MBD3 MDM2 NTAQ1 P4HA3 PHKG2 POLL PSMC1 SEPTIN5 SMARCD1 TNIP3 TP53 TRIM28	4 interacting genes: COQ7 COQ9 MAGEA2 MAGEA2B
Entrez ID		4101	51117
HPRD ID		02165	16741
Ensembl ID		ENSG00000268606	ENSG00000167113
Uniprot IDs		P43356	Q9Y3A0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Antibiotic Response To UV-C Protein-containing Complex SUMO Transferase Activity	Negative Regulation Of Protein Acetylation Ubiquinone Biosynthesis Complex Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Ubiquinone Biosynthetic Process Ubiquinone Metabolic Process Quinone Metabolic Process Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Ketone Biosynthetic Process Cellular Senescence Ketone Metabolic Process Negative Regulation Of Post-translational Protein Modification Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination PML Body 3-demethoxyubiquinol 3-hydroxylase Activity 3-demethoxyubiquinone 3-hydroxylase (NADH) Activity Isoprenoid Binding Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Extrinsic Component Of Mitochondrial Inner Membrane Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Catalytic Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Modification Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Mitochondrial Inner Membrane Small Molecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Modification Process Determination Of Adult Lifespan Negative Regulation Of Biosynthetic Process Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Monooxygenase Activity Aerobic Electron Transport Chain