P4HA3 and WDR62

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		P4HA3	WDR62
Description		prolyl 4-hydroxylase subunit alpha 3	WD repeat domain 62
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity	Protein Binding
	Biological Process	Collagen Fibril Organization	Positive Regulation Of Neuroblast Proliferation Mitotic Spindle Organization Centriole Replication Nervous System Development Cerebral Cortex Development Neurogenesis Regulation Of Neuron Differentiation Regulation Of Centrosome Cycle Positive Regulation Of Neuron Migration
Pathways		Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Hippocampal atrophy ( 25625606)
Interacting Genes		49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A	10 interacting genes: DYRK2 ENKD1 LRIF1 MAGEB4 MAPK8 MAPK9 P4HA3 RALY TBC1D23 TBP
Entrez ID		283208	284403
HPRD ID		16413	10721
Ensembl ID		ENSG00000149380	ENSG00000075702
Uniprot IDs		Q7Z4N8	A0A7P0T9D9 A0A7P0TAK3 A0A7P0Z436 O43379
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding	JUN Kinase Activity Regulation Of RNA Metabolic Process MAP Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Fc-epsilon Receptor Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process JUN Phosphorylation
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