MAGEA2 and PHKG2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MAGEA2	PHKG2
Name		MAGE family member A2	phosphorylase kinase catalytic subunit gamma 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus PML Body	Cytoplasm Cytosol Phosphorylase Kinase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Tau-protein Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction By P53 Class Mediator Cellular Senescence Negative Regulation Of Protein Acetylation	Glycogen Metabolic Process Glycogen Catabolic Process Generation Of Precursor Metabolites And Energy Protein Phosphorylation Signal Transduction Positive Regulation Of Glycogen Catabolic Process
Pathways		None	Glycogen breakdown (glycogenolysis)
Diseases		None	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: IRAK1	None recorded
Interacting Genes		21 interacting genes: ACSM1 ANKRD45 BEX1 BEX2 CCDC185 CEP57 COQ4 COX7C DYNLRB1 MBD3 MDM2 NTAQ1 P4HA3 PHKG2 POLL PSMC1 SEPTIN5 SMARCD1 TNIP3 TP53 TRIM28	4 interacting genes: DAPK1 MAGEA2 MAGEA2B PHKG1
Entrez ID		4101	5261
HPRD ID		02165	01405
Ensembl ID		ENSG00000268606	ENSG00000156873
Uniprot IDs		P43356	P15735
PDB IDs		Not available	2Y7J
GO Terms Enriched among Interactors		Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Antibiotic Response To UV-C Protein-containing Complex SUMO Transferase Activity	Negative Regulation Of Protein Acetylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Cellular Senescence DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Negative Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination PML Body Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding DNA-binding Transcription Factor Binding Calmodulin Binding Regulation Of Protein Ubiquitination Regulation Of NMDA Receptor Activity Phosphorylase Kinase Activity Regulation Of Post-translational Protein Modification Phosphorylase Kinase Complex Ubiquitin Protein Ligase Binding Positive Regulation Of Catalytic Activity Cellular Response To Hydroperoxide Defense Response To Tumor Cell Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Protein Serine/threonine Kinase Activity Signal Transduction Regulation Of Neurotransmitter Receptor Activity Intracellular Signal Transduction Syntaxin-1 Binding Response To Hydroperoxide Protein Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Catalytic Activity Macromolecule Metabolic Process Regulation Of Response To Tumor Cell Kinase Activity Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Receptor Activity Regulation Of Protein Modification Process Organelle Negative Regulation Of Biosynthetic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process