ARSA and BMPR2

Number of citations of the paper that reports this interaction (PMID 15188402)
20

Data Source:
HPRD (in vitro)

		ARSA	BMPR2
Gene Name		arylsulfatase A	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Extracellular Space Lysosome Endosome Endoplasmic Reticulum Lumen Integral Component Of Membrane Extrinsic Component Of External Side Of Plasma Membrane Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Sulfuric Ester Hydrolase Activity	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Autophagy Binding Of Sperm To Zona Pellucida Central Nervous System Development Response To Nutrient Response To PH Response To Estrogen Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Response To Ethanol Response To Methylmercury	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Post-translational protein modification The activation of arylsulfatases Gamma carboxylation, hypusine formation and arylsulfatase activation	Signaling by BMP
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		7 interactors: BMPR2 CETN2 CLEC4G CTSL GAL3ST1 PPIC TRIP13	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		410	659
HPRD ID		09617	02880
Ensembl ID			ENSG00000204217
Uniprot IDs		B4DVI5 P15289	Q13873
PDB IDs		1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK	2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Spermatogenesis Male Gamete Generation Gamete Generation Regulation Of Lung Blood Pressure Macrophage Apoptotic Process Galactosylceramide Biosynthetic Process Negative Regulation Of Chondrocyte Proliferation Sexual Reproduction Multicellular Organismal Reproductive Process Negative Regulation Of Vasoconstriction Multicellular Organism Reproduction Reproduction Myeloid Cell Apoptotic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Inflammatory Cell Apoptotic Process Lymphatic Endothelial Cell Differentiation Single Organism Reproductive Process Cellular Response To Thyroid Hormone Stimulus Galactosylceramide Metabolic Process Lymphangiogenesis Reproductive Process Lymph Vessel Morphogenesis Female Meiosis I Glycoprotein Biosynthetic Process Centriole Replication Response To Thyroid Hormone Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Glycosylceramide Metabolic Process Glycosphingolipid Biosynthetic Process Cellular Response To Stress Glycoprotein Metabolic Process Response To Stress Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Synaptonemal Complex Assembly Cellular Metabolic Process Synaptonemal Complex Organization Oocyte Maturation Centriole Assembly Activin Receptor Signaling Pathway Male Meiosis I	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?		adrenaline approached ayurvedic clock digestive dilatation disturb external foods hemorrhoid hemorrhoidal hemorrhoids improper intero irregularity jimutaka kaphaja lepa lignocaine manual masses obliterating pile proctologists proctoscopic regularly sedentary sloughing visited	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?		adrenaline approached ayurvedic clock digestive dilatation disturb external foods hemorrhoid hemorrhoidal hemorrhoids improper intero irregularity jimutaka kaphaja lepa lignocaine manual masses obliterating pile proctologists proctoscopic regularly sedentary sloughing visited	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?