ACVR1B and IGSF1

Number of citations of the paper that reports this interaction (PMID 11266516)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ACVR1B	IGSF1
Gene Name		activin A receptor, type IB	immunoglobulin superfamily, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex Extracellular Vesicular Exosome	Extracellular Region Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding	Receptor Activity Protein Binding Coreceptor Activity Inhibin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Central Nervous System Development Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Regulation Of Transcription, DNA-templated Signal Transduction
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by NODAL
Drugs		Adenosine triphosphate
Diseases
GWAS		Urate levels ( 23263486)
Protein-Protein Interactions		20 interactors: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L OS9 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1	8 interactors: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10
Entrez ID		91	3547
HPRD ID		03193	02138
Ensembl ID		ENSG00000135503	ENSG00000147255
Uniprot IDs		P36896	Q8N6C5
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor SMAD Protein Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Signal Transduction BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cell Communication Positive Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Tissue Morphogenesis Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Mesoderm Development Regulation Of Signaling SMAD Protein Complex Assembly Heart Development Embryo Development Positive Regulation Of Phosphorylation Transcription Initiation From RNA Polymerase II Promoter	Activin Receptor Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Biomineral Tissue Development Regulation Of Ossification Positive Regulation Of Protein Metabolic Process Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Regulation Of Phosphorus Metabolic Process Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Tissue Development Regulation Of Signaling Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Tube Morphogenesis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Epithelium Development Mesoderm Development Embryo Development Regulation Of Protein Metabolic Process Positive Regulation Of Erythrocyte Differentiation Reproductive Process Gastrulation Embryonic Morphogenesis System Development Positive Regulation Of Cellular Metabolic Process Tube Development Development Of Primary Sexual Characteristics Regulation Of Cell Differentiation Regulation Of Erythrocyte Differentiation
Tagcloud ?		125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e
Tagcloud (Difference) ?		125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e
Tagcloud (Intersection) ?