ACVR1B and NODAL

Number of citations: 67 (PubMedID 28126904)
Data Source: BioGRID (pull down)

		ACVR1B	NODAL
Name		activin A receptor type 1B	nodal growth differentiation factor
Structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Receptor Complex Activin Receptor Complex Serine/threonine Protein Kinase Complex	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding I-SMAD Binding	Cytokine Activity Protein Binding Growth Factor Activity Morphogen Activity Receptor Ligand Activity Type I Activin Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Gastrulation With Mouth Forming Second Formation Of Primary Germ Layer Mesoderm Formation Trophectodermal Cell Differentiation Trophectodermal Cellular Morphogenesis Neural Fold Formation Liver Development Placenta Development Embryonic Placenta Development Maternal Placenta Development Vasculature Development Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Nervous System Development Brain Development Endoderm Development Heart Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Signal Transduction Polarity Specification Of Proximal/distal Axis Regulation Of Gastrulation Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Development Cell Migration Stem Cell Population Maintenance Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Floor Plate Morphogenesis Somatic Stem Cell Population Maintenance Embryonic Heart Tube Development Endodermal Cell Differentiation Nodal Signaling Pathway Cell Migration Involved In Gastrulation Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Axial Mesodermal Cell Fate Specification Mesendoderm Development Digestive Tract Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryonic Cranial Skeleton Morphogenesis Tissue Morphogenesis Formation Of Anatomical Boundary Positive Regulation Of Epithelial Cell Proliferation Digestive System Development Embryonic Process Involved In Female Pregnancy Maternal Process Involved In Parturition Positive Regulation Of SMAD Protein Signal Transduction Left Lung Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Epiblast Cell-extraembryonic Ectoderm Cell Signaling Positive Regulation Of ERK1 And ERK2 Cascade Primitive Streak Formation Apoptotic Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Stem Cell Population Maintenance Negative Regulation Of Reproductive Process
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin	Signaling by NODAL Regulation of signaling by NODAL
Drugs		ATP Fostamatinib	None
Diseases		None	Heterotaxy; Situs ambiguus
GWAS		Adenocarcinoma ( 26732429 ) Age-related hearing impairment ( 24939585 ) Granulocyte count ( 27863252 ) Hematocrit ( 29403010 ) Hemoglobin ( 29403010 ) Lung cancer ( 26732429 ) Neutrophil count ( 27863252 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Serum CC16 levels ( 32839289 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Urate levels ( 23263486 )	No GWAS studies recorded
Interacting Genes		22 interacting genes: ACVR2B BAG6 BAMBI BMPR2 CRIPTO FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TGFBRAP1	6 interacting genes: ACVR1B ACVR2A ACVR2B CRIPTO KRT31 KRTAP6-3
Entrez ID		91	4838
HPRD ID		03193	08370
Ensembl ID		ENSG00000135503	ENSG00000156574
Uniprot IDs		P36896	Q96S42
PDB IDs		7MRZ 7OLY	4N1D
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of SMAD Protein Signal Transduction Activin Receptor Binding SMAD Protein Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Heteromeric SMAD Protein Complex Anatomical Structure Morphogenesis Lung Development Positive Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Mesoderm Formation Nodal Signaling Pathway Gastrulation Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Embryonic Pattern Specification Formation Of Primary Germ Layer Gastrulation With Mouth Forming Second Regionalization Positive Regulation Of Ovulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Growth Factor Activity Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Axis Specification Roof Of Mouth Development Regulation Of Metabolic Process Response To Growth Factor Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Activin Responsive Factor Complex Cell Differentiation	Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ossification Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Cellular Response To Growth Factor Stimulus Response To Growth Factor Activin Receptor Activity, Type I Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Nodal Signaling Pathway Gastrulation With Mouth Forming Second Anterior/posterior Pattern Specification Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Positive Regulation Of Erythrocyte Differentiation Regionalization Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation Regulation Of Erythrocyte Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Protein Serine/threonine Kinase Activity Pattern Specification Process Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Protein Kinase Activity Odontogenesis Positive Regulation Of Myeloid Cell Differentiation Anatomical Structure Morphogenesis Penile Erection Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Inhibin-betaglycan-ActRII Complex Nodal Binding