CEBPA and MRE11

Number of citations of the paper that reports this interaction (PubMedID 34189442)
73

Data Source:
BioGRID (unspecified method)

		CEBPA	MRE11
Description		CCAAT enhancer binding protein alpha	MRE11 double strand break repair nuclease
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Nuclear Matrix Protein-containing Complex Rb-E2F Complex CHOP-C/EBP Complex RNA Polymerase II Transcription Regulator Complex C/EBP Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break BRCA1-C Complex Chromosomal Region
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Domain Specific Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding STAT Family Protein Binding DNA-binding Transcription Factor Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding
	Biological Process	Urea Cycle Negative Regulation Of Transcription By RNA Polymerase II Liver Development Embryonic Placenta Development Epithelial Cell Maturation Osteoblast Development Generation Of Precursor Metabolites And Energy DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase I Acute-phase Response Mitochondrion Organization Notch Signaling Pathway Response To Nutrient Memory Cholesterol Metabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Cell Differentiation Macrophage Differentiation Lung Development Granulocyte Differentiation Animal Organ Regeneration Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Vitamin B2 Regulation Of Cell Population Proliferation Glucose Homeostasis Positive Regulation Of Macrophage Activation Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Positive Regulation Of Inflammatory Response White Fat Cell Differentiation Brown Fat Cell Differentiation Regulation Of Cell Cycle Lipid Homeostasis Interleukin-6-mediated Signaling Pathway White Fat Cell Proliferation Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Response To Phenylpropanoid Energy Homeostasis Integrated Stress Response Signaling Negative Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Signaling Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Chromosome Organization Meiotic Cell Cycle R-loop Processing Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases		Acute myeloid leukemia (AML)	Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Asthma ( 34103634 31959851 30929738) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Basophil count ( 28031487) Birth weight ( 31043758) Hip index ( 34021172) Mastocytosis (KIT D816V positive) ( 33421400) Red blood cell count ( 29403010) Visceral adipose tissue volume ( 34128465) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count (basophil) ( 29403010 28158719)
Interacting Genes		831 interacting genes: AARS1 ABCE1 ABCF1 ACLY ACSL1 ACTG1 ACTN1 ACTN4 ACTR1A ACTR2 ADAR AHCY AHSA1 AIMP2 AIP AK6 ALDOA ALKBH5 ALYREF ANAPC7 ANLN ANXA5 ANXA6 AP1B1 AP2B1 AP2M1 APEH APEX1 AR ARHGAP15 ARHGDIA ARHGDIB ARHGEF2 ARL6IP4 ARPC1B ARPC3 ASNS ATF2 ATF4 ATF5 ATIC ATP1A1 ATP2A2 ATXN2 ATXN2L AURKA BAG1 BAG6 BANF1 BATF BATF2 BATF3 BCAP31 BCAT1 BCL2L2 BCLAF1 BIN2 BLMH BTF3 BTF3L4 BUB3 BUD23 BUD31 BZW1 BZW2 C11orf58 C19orf53 C1QBP C2orf49 CAB39 CACYBP CAD CALU CAMK2G CAND1 CAP1 CAPG CAPRIN1 CAPZA1 CAPZB CC2D1A CCAR2 CCDC12 CCDC7 CCNB1 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 CCZ1 CDC42 CDK1 CDK13 CDK2 CDK4 CDK7 CDK8 CDK9 CDKN1A CDKN2AIP CDKN3 CDX1 CEBPB CEBPD CEBPE CEBPG CELF1 CELF2 CEP170 CGGBP1 CHD4 CHD8 CHEK1 CHMP4B CHMP5 CHTOP CIAPIN1 CIRBP CIT CKAP5 CLASP1 CLIC1 CLINT1 CLTA CLTB CLTC CMSS1 CNOT1 COPS3 COPS4 COPS5 CORO1A CORO1C CPNE1 CPSF6 CPSF7 CREBBP CRIPT CSDE1 CSNK1A1 CSNK2A1 CSNK2A2 CSTF3 CTNNB1 CTPS1 CUL1 CUL3 CUTA CZIB DARS1 DAZAP1 DBP DCD DCPS DCXR DDX1 DDX17 DDX19B DDX23 DDX39A DDX3X DDX41 DDX49 DDX5 DDX55 DDX6 DEK DHX15 DIDO1 DIMT1 DNAJB1 DNAJC8 DNAJC9 DNM2 DNMT1 DOCK2 DOCK8 DPP3 DRG1 DTYMK DYNC1H1 DYNC1LI1 DYNLRB1 ECPAS EDC4 EDF1 EEF1A1 EEF1B2 EEF1D EEF1E1 EEF1G EEF2 EEFSEC EIF1 EIF2A EIF2S1 EIF2S2 EIF2S3 EIF4A1 EIF4A3 EIF4B EIF4E EIF4G2 EIF4H EIF5 EIF5B ELAVL1 ELMO1 ELOB ELOC EMG1 ENY2 EP300 EP400 EPRS1 ERGIC3 ERP29 ESR1 ETF1 ETV6 EVL EWSR1 EXOSC10 EZR FAM120A FAM136A FAM32A FAM76B FAM98B FANCI FARSB FASN FDPS FEN1 FIP1L1 FKBP3 FKBP4 FKBP5 FLNA FLYWCH2 FNBP1 FOS FOSL1 FOXK1 FRG1 FUBP1 FUBP3 FUS G3BP1 G3BP2 GABARAPL2 GABPA GABPB1 GAPDH GARS1 GATA2 GATAD2A GBE1 GDI2 GET4 GLO1 GLRX3 GLTP GMFG GMNN GMPS GOPC GRB2 GRWD1 GSK3B GSN GSPT1 GSTP1 GTF2F1 GTF2F2 GTF2I GTPBP1 GTSF1 H1-2 H1-5 H2AC20 H2BC15 H3-3A H4C1 HADHA HADHB HAT1 HCFC1 HDAC1 HDAC2 HDGF HDLBP HEATR3 HEBP2 HELLS HEXIM1 HLTF HMGA1 HMGB1 HMGB2 HMGB3 HMGCS1 HMGN1 HMGN2 HMGN4 HMMR HNF1A HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPAB HNRNPD HNRNPDL HNRNPK HNRNPL HNRNPLL HNRNPR HNRNPU HNRNPUL1 HOMER3 HPCAL1 HPRT1 HSD17B4 HSPA1B HSPA4 HSPH1 HYOU1 IARS1 IFI16 IGF2BP1 IGF2BP2 IGF2BP3 IK ILF2 ILF3 ILK IMPDH2 INPP5D INTS12 IPO11 IPO7 IQGAP1 IRF2BP1 IRF2BP2 ITPA KARS1 KAT2A KAT8 KCNAB2 KHDRBS1 KHSRP KIF11 KIF2A KIF2C KIF4A KIF5B KIFC1 KNTC1 KPNB1 LARP1 LARS1 LASP1 LCP1 LDHA LDHB LIG1 LIMD2 LMAN1 LRWD1 LSM12 LSM14A LSM14B LSM2 LSM5 LSM6 LSM7 MAGOHB MAP2K7 MAP4 MAP7D1 MAPK1 MAPK8 MARS1 MAT2A MAT2B MBNL1 MCM4 MCM5 MCM7 MCTS1 MED1 MED10 MED12 MED14 MED15 MED16 MED17 MED21 MED22 MED23 MED24 MED27 MED28 MED29 MED4 MED6 MED8 METAP2 MIF MITD1 MKI67 MLKL MNDA MORC2 MORF4L1 MPO MRE11 MRTO4 MSH2 MSH6 MSN MSX2 MTA2 MTHFD1 MTPN MTREX MVK MYC MYCBP2 MYL6 MZT2B NAA10 NAA15 NAA50 NAE1 NARS1 NCAPD3 NCAPG2 NCF1 NCOA6 NEDD1 NEK6 NELFA NELFB NELFE NFYA NHERF1 NIFK NME2 NOC4L NOLC1 NONO NOP14 NOP2 NOP58 NOSIP NPEPPS NR3C1 NSFL1C NSUN2 NSUN5 NTPCR NUCKS1 NUDC NUDT16L1 NUDT21 NUP153 NUP50 NUP93 NUSAP1 NUTF2 NXF1 OLA1 ORC3 ORC5 ORC6 OTUB1 PA2G4 PABPC1 PABPC4 PAF1 PAICS PAK2 PARP1 PCBP2 PCLAF PCM1 PCMT1 PCNP PDAP1 PDCD5 PDCD6 PDIA3 PDIA4 PDS5A PDS5B PEBP1 PES1 PFDN1 PFDN2 PFDN5 PFDN6 PFKL PFKM PGAM1 PGK1 PHF6 PHGDH PIAS1 PIN1 PIN4 PKM PLIN3 PLK1 PLRG1 PNP POLDIP3 POLR1D PPA1 PPAT PPIB PPIH PPIL2 PPME1 PPP2CA PPP3CA PPP4R2 PPP4R3A PPP5C PQBP1 PRAM1 PRC1 PRDX1 PRKDC PRKRIP1 PRMT1 PRPF19 PRPF3 PRPF31 PRPF38B PRPF39 PRPF4 PRPF6 PRPS1 PRRC2A PRRC2C PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB7 PSMC1 PSMC3 PSMC4 PSMC6 PSMD10 PSMD11 PSMD12 PSMD14 PSMD6 PSMD7 PSME1 PSME2 PSME3 PSMG1 PSPC1 PTBP1 PUF60 PUM3 PURB PYGL QKI RAB10 RAB2A RAB3GAP2 RAC1 RAD23A RAD23B RAD50 RAE1 RANBP1 RANBP2 RARA RARB RARS1 RASGRF1 RASGRP2 RAVER1 RB1 RBL1 RBM14 RBM15 RBM17 RBM22 RBM26 RBM27 RBM28 RBM3 RBM33 RBM39 RBMX RCC1 RCC2 RCOR1 RECQL RFC1 RFC2 RFC3 RFC4 RFC5 RHOA RHOG RNGTT RNH1 RPA1 RPA2 RPL9 RPP30 RPS28 RPS29 RRM1 RSL1D1 RTCB RTRAF RUNX1 RUVBL2 S100A11 S100P SAE1 SAFB SAFB2 SAR1A SARNP SART1 SBDS SCAF4 SCP2 SEH1L SEPTIN14 SEPTIN2 SEPTIN6 SEPTIN9 SERF2 SF1 SF3A1 SF3A2 SF3B6 SFPQ SIN3A SKP2 SLAIN2 SLBP SLC25A5 SLC3A2 SLFN11 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCC2 SMARCD2 SMARCE1 SMC1A SMC2 SMC3 SMC4 SMCHD1 SMNDC1 SMS SMU1 SND1 SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNW1 SNX9 SORD SOX10 SOX8 SPAST SPI1 SPR SRA1 SRM SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRRM2 SRSF7 SSB SSBP1 SSRP1 STAT1 STAU1 STEEP1 STK10 STMN1 STRAP SUB1 SUGP1 SUGP2 SUGT1 SUMO1 SUMO2 SUMO3 SURF4 SYK SYNCRIP TADA3 TALDO1 TAOK3 TARS1 TBCA TBL1XR1 TCEA1 TCERG1 TCP1 TEX30 THAP11 THOC2 THRAP3 THYN1 TIAL1 TIPRL TKT TLN1 TM9SF3 TMA16 TMA7 TMED10 TMPO TNPO2 TNPO3 TOGARAM2 TOMM34 TOP1 TOP2A TOP2B TP53 TP53BP1 TPI1 TPP2 TPT1 TPX2 TRIB2 TRIM25 TRIM33 TRIM4 TRIR TRRAP TSN TSNAX TTC9C TTF2 TTLL12 TUBB4A TUBB4B TUBG1 TUBGCP2 TUBGCP3 TWF2 TXLNA TXLNG TXN TXNDC5 TXNL1 TXNRD1 U2SURP UBA1 UBA2 UBE2I UBE2K UBQLN1 UBR5 UBTF UBXN1 UCHL3 UNG UPF1 UPF3B USP14 USP22 USP39 VARS1 VASP WARS1 WBP11 WDR74 WDR82 WIPF1 WRNIP1 XPO1 XPO5 XPOT XRCC5 XRCC6 XRN2 YBX1 YY1 ZBTB16 ZC3H11A ZC3H15 ZFR ZMAT2 ZNF207 ZRANB2 ZW10 ZYX	27 interacting genes: ATM ATR CCNE1 CDK2 CDX2 CEBPA DCLRE1C DYNLL1 EP300 FANCD2 GRB2 H1-2 H2AX H4C1 LIG1 LOX MAPK8IP2 NBN NEK1 NKX3-1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6
Entrez ID		1050	4361
HPRD ID		00296	02889
Ensembl ID		ENSG00000245848	ENSG00000020922
Uniprot IDs		P49715	F8W7U8 P49959 Q05D78
PDB IDs		6DC0 8K8C	3T1I 7ZQY 8BAH 8K00
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleoplasm Nucleus Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Cytosol Cytoplasm MRNA Metabolic Process Macromolecule Metabolic Process MRNA Processing RNA Splicing RNA Processing Spliceosomal Complex RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Binding MRNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Organization Catalytic Step 2 Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Nucleotide Binding ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Protein-containing Complex Assembly Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Positive Regulation Of Biosynthetic Process Cadherin Binding Regulation Of DNA Metabolic Process Chromatin Binding Ficolin-1-rich Granule Lumen Nucleolus Regulation Of Gene Expression Cellular Component Assembly Proteasome Complex Nuclear Speck Negative Regulation Of Macromolecule Metabolic Process Cytoplasmic Stress Granule ATP Hydrolysis Activity Positive Regulation Of RNA Biosynthetic Process	DNA Damage Response Telomere Organization DNA Metabolic Process Telomere Maintenance Chromosome Organization DNA Repair Double-strand Break Repair DNA Strand Resection Involved In Replication Fork Processing Chromosome, Telomeric Region Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage DNA Recombination DNA Damage Checkpoint Signaling Protein Localization To Chromosome Histone H2AXS139 Kinase Activity Organelle Organization Negative Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Recombinational Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Negative Regulation Of Cell Cycle Somatic Cell DNA Recombination Regulation Of DNA Metabolic Process V(D)J Recombination Negative Regulation Of Cell Cycle Process Chromosome Response To Gamma Radiation Regulation Of Cell Cycle Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Process Response To Radiation Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Response To Stress Mitotic DNA Integrity Checkpoint Signaling Regulation Of DNA Recombination Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Capping Nonhomologous End Joining Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle
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