SMAD3 and PPP2R1A

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD3	PPP2R1A
Gene Name		SMAD family member 3	protein phosphatase 2, regulatory subunit A, alpha
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Receptor Complex SMAD Protein Complex SMAD2-SMAD3 Protein Complex	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding Protein Binding Transcription Factor Activity RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Collagen Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Phosphatase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Enhancer Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Co-SMAD Binding R-SMAD Binding	Antigen Binding Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Somitogenesis Liver Development Negative Regulation Of Protein Phosphorylation Heart Looping Osteoblast Development Immune System Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Endoderm Development Embryonic Pattern Specification Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Primary MiRNA Processing Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Transforming Growth Factor Beta3 Production Activin Receptor Signaling Pathway Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Catenin Import Into Nucleus Intracellular Signal Transduction Nodal Signaling Pathway Wound Healing T Cell Activation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Immune Response Protein Stabilization Positive Regulation Of Positive Chemotaxis Regulation Of Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Pericardium Development Transdifferentiation SMAD Protein Signal Transduction Negative Regulation Of Wound Healing Lens Fiber Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Organelle Organization Chromosome Segregation Mitotic Nuclear Envelope Reassembly RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Gene Expression Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cell Differentiation Peptidyl-serine Dephosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Signaling by FGFR in disease Integration of energy metabolism misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated Toll Like Receptor TLR1:TLR2 Cascade Glucose metabolism Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated MyD88 dependent cascade initiated on endosome Glycogen storage diseases Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases Recruitment of mitotic centrosome proteins and complexes misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling S45 mutants of beta-catenin aren't phosphorylated Spry regulation of FGF signaling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Platelet sensitization by LDL Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Adaptive Immune System MASTL Facilitates Mitotic Progression Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding G2/M Transition disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System Nonsense-Mediated Decay (NMD) E2F mediated regulation of DNA replication ERKs are inactivated G1 Phase CTLA4 inhibitory signaling Signaling by FGFR Cyclin D associated events in G1 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Signaling by GPCR Mitotic Prophase TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Glycolysis Regulation of PLK1 Activity at G2/M Transition RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Myoclonic epilepsy of Lafora Toll Like Receptor 9 (TLR9) Cascade Initiation of Nuclear Envelope Reformation ERK/MAPK targets truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Mitotic Metaphase and Anaphase PP2A-mediated dephosphorylation of key metabolic factors Mitotic Prometaphase Organelle biogenesis and maintenance Costimulation by the CD28 family Toll Like Receptor 7/8 (TLR7/8) Cascade Mitotic Anaphase APC truncation mutants are not K63 polyubiquitinated M Phase Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane DARPP-32 events Nuclear Envelope Reassembly Signalling by NGF MAP kinase activation in TLR cascade Assembly of the primary cilium NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Centrosome maturation Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Asthma ( 20860503) Corneal structure ( 23291589) Coronary heart disease ( 17634449) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		268 interactors: AATF ACTB AES AKT1 ANAPC10 ANK3 APMAP APOB APP AR ARHGEF6 ATF2 ATF3 AXIN1 AXIN2 BLZF1 BPTF BRCA1 BRCA2 BTRC C10orf54 CAMK2G CCDC33 CDC16 CDC25A CDC27 CDK2 CDK4 CDK8 CDK9 CEBPA CEBPB CEBPD CFDP1 CFH CFLAR CHRD CLASRP CORO1A CPSF7 CPTP CREBBP CSH2 CSNK1D CSNK1G2 CTCF CTNNB1 CUL1 CXXC5 CYP11A1 DAB2 DACH1 DDX5 DEDD DNAJB4 DVL1 E2F4 E2F5 EBI3 EID2 EIF4ENIF1 EP300 EPAS1 EPB41 ERBB2IP ESR1 ESR2 ETS1 FBLN1 FHL2 FHL3 FLI1 FLNA FOS FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 GGA1 GIT2 GLI3 GMEB1 GSC GSK3B GTF2IRD1 HDAC1 HDAC4 HDAC5 HEY1 HEYL HGS HIPK2 HIVEP1 HMGA2 HNF4A HNRNPK HOXC11 HP HSPA4 IL37 ISL1 ITCH JPH3 JUN JUNB JUND KANSL1 KAT2B KDM2A KMT2B KPNB1 KRT10 KRT2 LBP LCK LEF1 LMNA MAGI2 MAP3K7 MAPK1 MAPK14 MAPK8 MAPK9 MAX MBD1 MCM3AP MDM4 MECOM MED15 MEN1 MEOX2 MTF2 MYC MYD88 MYO5B MYOCD MYOD1 NCOA6 NEDD4 NEDD4L NEDD9 NF1 NFYC NOTCH1 NOTCH4 NR3C1 NR4A1 NUP153 NUP214 OTUB1 PAEP PAPPA PARD3 PARD3B PARP4 PAX8 PCDH1 PCK2 PEX6 PHC2 PIAS2 PIAS3 PIAS4 PIK3CA PIN1 PLAG1 PLAGL1 PLG PML PPM1A PPP1R12C PPP2R1A PRDM4 PRKAR1B PRKAR2A PROX1 PRTN3 PSMD11 RAB38 RANBP9 RARG RASD2 RASL12 RBL1 RBX1 RCVRN RELA RIOK2 RIT1 RNF111 RNF31 RPA1 RPLP0 RRAS2 RUNX2 RUNX3 S100A4 SAP130 SERTAD1 SETD2 SF3A1 SF3B2 SIN3A SKI SKIL SKOR2 SMAD1 SMAD2 SMAD4 SMAD9 SMURF1 SMURF2 SNRNP70 SNW1 SP1 SPTBN1 SQSTM1 SREBF2 SRY SS18L1 ST6GALNAC2 STRAP STUB1 SVEP1 TANK TDP2 TEKT4 TF TFE3 TGFBR1 TGFBR2 TGIF1 TGIF2 TGM2 TLR4 TMED1 TOB1 TP53 TP73 TPM3 TSC2 TSC22D4 UBQLN4 UCHL5 USP15 USP7 VDR VIM WEE1 WWP1 WWP2 XRCC6 YBX1 YY1 ZBTB16 ZBTB3 ZC3H12A ZCCHC14 ZDHHC4 ZEB1 ZEB2 ZFYVE9 ZMYM2 ZMYND11 ZNF329 ZNF8 ZNF83	39 interactors: AIMP2 AKT1 ARIH2 CDK1 CSDC2 EEF2 GNA12 GRIN1 GRIN2D HSF2 HSPD1 IPO9 MAP3K7 MAPK6 MCM3 PARK7 PLA2G16 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP4C PPP5C PRDX1 PRDX2 RAB11A RAB18 RAB7A RAP1A SGOL1 SGOL2 SLC6A2 SMAD2 SMAD3 STRN STRN3 TAB1 TRADD ZFYVE9
Entrez ID		4088	5518
HPRD ID		04380	16184
Ensembl ID		ENSG00000166949
Uniprot IDs		P84022 Q9P0T0	A8K7B7 P30153
PDB IDs		1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2	1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Response To Growth Factor Cellular Response To Organic Substance RNA Metabolic Process Gene Expression Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stimulus Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Organ Development Signal Transduction Developmental Process	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Ras Protein Signal Transduction Signaling Intracellular Signal Transduction Signal Transduction Cell Communication Positive Regulation Of Cellular Metabolic Process SMAD Protein Complex Assembly Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cellular Response To Stimulus Cell Cycle Process Response To Organic Substance Cell Cycle Mitotic Cell Cycle Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Protein Complex Assembly Regulation Of Protein Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Metabolic Process Response To Organic Cyclic Compound Positive Regulation Of Protein Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Modification Process Response To Transforming Growth Factor Beta Positive Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Cellular Response To Reactive Oxygen Species Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hydrogen Peroxide Metabolic Process Programmed Cell Death Cellular Component Assembly Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Localization Toll-like Receptor Signaling Pathway
Tagcloud ?		adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad4 smads squelching tgf transactivation transduce	arid1a carcinomas ccc concurrent constitute ctnnb1 endometrial endometrioid endometrium hepatocyte hnf1beta immunophenotype mismatch morphologically mutated napsin oestrogen oncogenesis pole predominance prototypical pten pure rigorously serous tp53 tumours twelve underscore
Tagcloud (Difference) ?		adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad4 smads squelching tgf transactivation transduce	arid1a carcinomas ccc concurrent constitute ctnnb1 endometrial endometrioid endometrium hepatocyte hnf1beta immunophenotype mismatch morphologically mutated napsin oestrogen oncogenesis pole predominance prototypical pten pure rigorously serous tp53 tumours twelve underscore
Tagcloud (Intersection) ?