SMAD3 and DNAJB4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SMAD3	DNAJB4
Description		SMAD family member 3	DnaJ heat shock protein family (Hsp40) member B4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Ciliary Basal Body Receptor Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Z Disc
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Collagen Binding Beta-catenin Binding Zinc Ion Binding Nuclear Receptor Binding DEAD/H-box RNA Helicase Binding Enzyme Binding Protein Kinase Binding Phosphatase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Nuclear Mineralocorticoid Receptor Binding Sterol Response Element Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	ATPase Activator Activity Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Skeletal System Development Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Somitogenesis Release Of Cytochrome C From Mitochondria Liver Development Heart Looping Osteoblast Development Immune System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway JNK Cascade Gastrulation Endoderm Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Embryonic Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Adrenal Gland Development Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Thyroid Gland Development Primary MiRNA Processing Positive Regulation Of Chondrocyte Differentiation Developmental Process Positive Regulation Of Interleukin-1 Beta Production Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Transforming Growth Factor Beta3 Production Activin Receptor Signaling Pathway Negative Regulation Of Osteoblast Proliferation Nodal Signaling Pathway Wound Healing T Cell Activation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell-cell Junction Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Immune Response Protein Stabilization Positive Regulation Of Positive Chemotaxis Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Stress Fiber Assembly Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Focal Adhesion Assembly Pericardium Development Transdifferentiation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Negative Regulation Of Wound Healing Trophoblast Cell Migration Negative Regulation Of Lung Blood Pressure Lens Fiber Cell Differentiation Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To Angiotensin	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Response To Heat
Pathways		Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310 30013184) Allergy ( 27182965) Appendicular lean mass ( 33097823) Asthma ( 20860503 31619474 31361310 31959851 32296059 29273806 27182965 29785011 34103634 30929738) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Central corneal thickness ( 31798171 32528159 29760442) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer or advanced adenoma ( 30510241) Corneal astigmatism ( 30306274) Corneal structure ( 23291589) Coronary artery disease ( 32469254 29212778 33020668 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449) Crohn's disease ( 28067908 21102463) Dental caries (decayed and filled deciduous teeth) ( 31533690) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 34506852) Estimated glomerular filtration rate ( 31015462 31152163) Femoral neck bone mineral density ( 29499414) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Height ( 31562340 28552196) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 23128233 28067908) Intraocular pressure ( 29235454 29617998 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Keratoconus ( 33649486) Lumbar spine bone mineral density ( 29499414) Lung cancer (smoking interaction) ( 24658283) Lung function (FVC) ( 30061609) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Metabolite levels ( 23823483) Myocardial infarction ( 26343387 33532862) Offspring birth weight ( 31043758) Osteoarthritis (hip) ( 30374069) Osteoarthritis of the hip or knee ( 30664745) Pediatric autoimmune diseases ( 26301688) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Restless legs syndrome ( 29029846) Self-reported allergy ( 23817569) Spontaneous dizygotic twinning ( 27132594) Sum eosinophil basophil counts ( 27863252) Thyroid cancer ( 28195142) Ulcerative colitis ( 28067908) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 30224653) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference ( 25673412)
Interacting Genes		280 interacting genes: AATF ACTB AKT1 ANAPC10 ANK3 APMAP APOB APP AR ARHGEF6 ATF2 ATF3 AXIN1 AXIN2 BLZF1 BPTF BRCA1 BRCA2 BTRC CAMK2G CCDC198 CCDC33 CDC16 CDC25A CDC27 CDK2 CDK4 CDK8 CDK9 CEBPA CEBPB CEBPD CFDP1 CFH CFLAR CHRD CLASRP CORO1A CPSF7 CPTP CREBBP CRX CSH2 CSNK1D CSNK1G2 CTCF CTNNB1 CUL1 CXXC5 CYP11A1 DAB2 DACH1 DDX5 DEDD DNAJB4 DNAJB5 DNMT3L DVL1 E2F4 E2F5 EBI3 EID2 EIF4B EIF4ENIF1 EP300 EPAS1 EPB41 ERBIN ESR1 ESR2 ETS1 FAM90A1 FBLN1 FHL2 FHL3 FLI1 FLNA FOS FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 GGA1 GIT2 GLI3 GMEB1 GSC GSK3B GTF2IRD1 HDAC4 HDAC5 HEY1 HEYL HGS HIF1A HIPK2 HIVEP1 HMGA2 HNF4A HNRNPK HOXC11 HP HSPA4 HYAL2 IL37 ISL1 ITCH JPH3 JUN JUNB JUND KANSL1 KAT2B KDM2A KMT2B KPNB1 KRT10 KRT2 LBP LCK LEF1 LEMD3 LINC00941 LMNA MAGI2 MAP3K7 MAPK1 MAPK14 MAPK8 MAPK9 MAX MBD1 MCM3AP MDM4 MECOM MED15 MEN1 MEOX2 MTF2 MYC MYD88 MYO5B MYOCD MYOD1 NCOA6 NEDD4 NEDD4L NEDD9 NFYC NOTCH1 NOTCH4 NR3C1 NUP153 NUP214 OTUB1 PAEP PAPPA PARD3 PARP4 PAX8 PCDH1 PCK2 PEX6 PHC2 PIAS2 PIAS3 PIAS4 PIK3CA PIN1 PLAG1 PLAGL1 PLG PML PPM1A PPP1R12C PPP2R1A PRDM4 PRKAR1B PRKAR2A PROX1 PRTN3 PSMB1 PSMD11 RAB38 RANBP9 RARG RASD2 RASL12 RBL1 RBPMS RBX1 RCVRN RELA RIOK2 RIT1 RNF111 RNF31 RPA1 RPLP0 RRAS2 RUNX2 RUNX3 S100A4 SAP130 SBK3 SERTAD1 SETD2 SF3A1 SF3B2 SIN3A SKI SKIL SKOR2 SMAD1 SMAD2 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNRNP70 SNW1 SP1 SPTBN1 SQSTM1 SREBF2 SRY SS18L1 ST6GALNAC2 STRAP STUB1 SVEP1 TANK TDP2 TEKT4 TF TFE3 TGFBR1 TGFBR2 TGIF1 TGIF2 TGM2 TLE5 TLR4 TMED1 TOB1 TP53 TP73 TPM3 TRIM33 TSC2 TSC22D4 UBQLN4 UCHL5 USP7 VDR VIM VSIR WEE1 WWP1 WWP2 XPO6 XRCC6 YBX1 YY1 ZBTB16 ZBTB3 ZC3H12A ZCCHC14 ZDHHC4 ZEB1 ZEB2 ZFYVE9 ZMYM2 ZMYND11 ZNF329 ZNF774 ZNF8 ZNF83	11 interacting genes: HSPA1A HSPA6 MDM2 OPRM1 PABPN1 POLR1D RUVBL2 SDIM1 SMAD3 TBL1X TBPL2
Entrez ID		4088	11080
HPRD ID		04380	07486
Ensembl ID		ENSG00000166949	ENSG00000162616
Uniprot IDs		A0AAQ5BHI7 H3BQ00 P84022 Q9P0T0	B4DNN2 Q9UDY4
PDB IDs		1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2 5OD6 5ODG 5XOC 6YIB 6ZMN
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin SMAD Binding DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Signal Transduction Regulation Of Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cell Communication RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Cell Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process	Regulation Of Protein Stability Protein Folding Cellular Heat Acclimation Protein Stabilization Unfolded Protein Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Enzyme Binding Disordered Domain Specific Binding Protein Refolding Transcription Corepressor Activity ATP-dependent Protein Folding Chaperone COP9 Signalosome Regulation Of Cellular Response To Stress Cellular Response To Alkaloid Cellular Response To Heat Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Folding Chaperone Heat Shock Protein Binding Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Lung Blood Pressure Positive Regulation Of Nucleocytoplasmic Transport Nuclear Mineralocorticoid Receptor Binding Regulation Of Nitric Oxide Metabolic Process Transcription Repressor Complex Response To Formaldehyde Cellular Response To Vitamin B1 Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Polynucleotide Adenylyltransferase Activity Ubiquitin Protein Ligase Binding Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP Hydrolysis Activity Denatured Protein Binding Negative Regulation Of RNA Metabolic Process Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Response To Lipid Positive Regulation Of Transforming Growth Factor Beta3 Production Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Response To Alkaloid Cellular Response To UV Nuclear DNA-directed RNA Polymerase Complex Ribonucleoprotein Complex
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