MARCKS and PRKCZ

Number of citations of the paper that reports this interaction (PMID 7588787)
13

Data Source:
BioGRID (enzymatic study)

		MARCKS	PRKCZ
Gene Name		myristoylated alanine-rich protein kinase C substrate	protein kinase C, zeta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Germinal Vesicle Extracellular Vesicular Exosome	Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Filamentous Actin Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase C Binding Calmodulin Binding Actin Filament Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Phospholipase Binding Insulin Receptor Substrate Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Energy Reserve Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Long-term Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Platelet Activation Negative Regulation Of Protein Complex Assembly Actin Cytoskeleton Reorganization Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-4 Production Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Negative Regulation Of Hydrolase Activity Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-10 Secretion
Pathways		Acetylcholine regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF GPVI-mediated activation cascade Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Height ( 20881960) Reasoning ( 21107309)
Protein-Protein Interactions		13 interactors: CALM2 CCNE1 CDK1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB PRKCZ SPP1 TOB1	84 interactors: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B HABP4 HIST1H1A HIST1H1B HIST3H3 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71
Entrez ID		4082	5590
HPRD ID		07519	01504
Ensembl ID		ENSG00000155130	ENSG00000067606
Uniprot IDs		P29966	Q05513
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-threonine Phosphorylation Regulation Of Protein Kinase Activity Phosphorylation Regulation Of Kinase Activity Cellular Response To Stimulus Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Metabolic Process Histone H3-T6 Phosphorylation Regulation Of Rhodopsin Mediated Signaling Pathway Signaling Cell Communication Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Rhodopsin Mediated Signaling Pathway Mitotic Cell Cycle Process Response To Stress Mitotic Nuclear Envelope Disassembly Response To Wounding Positive Regulation Of Cellular Metabolic Process Chromatin Organization Response To Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Intracellular Signal Transduction Mitotic Cell Cycle Histone Modification Nuclear Envelope Disassembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Blood Coagulation Hemostasis Phosphate-containing Compound Metabolic Process Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Response To Hormone Peptidyl-amino Acid Modification Nuclear Envelope Organization Positive Regulation Of Phospholipase Activity Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Response To Insulin Stimulus Chromosome Organization Mitotic Cell Cycle Phase Transition	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Defense Response Fc Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Fc-epsilon Receptor Signaling Pathway Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Apoptotic Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Death Apoptotic Process Response To Fibroblast Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Difference) ?		approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Intersection) ?