LYZ and CLU

Number of citations of the paper that reports this interaction (PMID 17407782)
11

Data Source:
BioGRID (pull down)

		LYZ	CLU
Gene Name		lysozyme	clusterin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite
	Molecular Function	Lysozyme Activity Identical Protein Binding	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding
	Biological Process	Retina Homeostasis Inflammatory Response Metabolic Process Cytolysis Defense Response To Bacterium	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Amyloids	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Height ( 18391951) Response to diuretic therapy ( 18591461)	Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		6 interactors: A2M CLU ELN LCN1 LTF UBC	44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT
Entrez ID		4069	1191
HPRD ID		01085	01706
Ensembl ID		ENSG00000090382	ENSG00000120885
Uniprot IDs		B2R4C5 P61626	P10909
PDB IDs		133L 134L 1B5U 1B5V 1B5W 1B5X 1B5Y 1B5Z 1B7L 1B7M 1B7N 1B7O 1B7P 1B7Q 1B7R 1B7S 1BB3 1BB4 1BB5 1C43 1C45 1C46 1C7P 1CJ6 1CJ7 1CJ8 1CJ9 1CKC 1CKD 1CKF 1CKG 1CKH 1D6P 1D6Q 1DI3 1DI4 1DI5 1EQ4 1EQ5 1EQE 1GAY 1GAZ 1GB0 1GB2 1GB3 1GB5 1GB6 1GB7 1GB8 1GB9 1GBO 1GBW 1GBX 1GBY 1GBZ 1GDW 1GDX 1GE0 1GE1 1GE2 1GE3 1GE4 1GEV 1GEZ 1GF0 1GF3 1GF4 1GF5 1GF6 1GF7 1GF8 1GF9 1GFA 1GFE 1GFG 1GFH 1GFJ 1GFK 1GFR 1GFT 1GFU 1GFV 1HNL 1I1Z 1I20 1I22 1INU 1IOC 1IP1 1IP2 1IP3 1IP4 1IP5 1IP6 1IP7 1IWT 1IWU 1IWV 1IWW 1IWX 1IWY 1IWZ 1IX0 1IY3 1IY4 1JKA 1JKB 1JKC 1JKD 1JSF 1JWR 1LAA 1LHH 1LHI 1LHJ 1LHK 1LHL 1LHM 1LMT 1LOZ 1LYY 1LZ1 1LZ4 1LZ5 1LZ6 1LZR 1LZS 1OP9 1OUA 1OUB 1OUC 1OUD 1OUE 1OUF 1OUG 1OUH 1OUI 1OUJ 1QSW 1RE2 1REM 1REX 1REY 1REZ 1TAY 1TBY 1TCY 1TDY 1UBZ 1W08 1WQM 1WQN 1WQO 1WQP 1WQQ 1WQR 1YAM 1YAN 1YAO 1YAP 1YAQ 207L 208L 2BQA 2BQB 2BQC 2BQD 2BQE 2BQF 2BQG 2BQH 2BQI 2BQJ 2BQK 2BQL 2BQM 2BQN 2BQO 2HEA 2HEB 2HEC 2HED 2HEE 2HEF 2LHM 2MEA 2MEB 2MEC 2MED 2MEE 2MEF 2MEG 2MEH 2MEI 2NWD 2ZIJ 2ZIK 2ZIL 2ZWB 3EBA 3FE0 3LHM 3LN2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Retina Homeostasis Regulation Of Immune System Process Platelet Degranulation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokine Production Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Extracellular Matrix Disassembly Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transferase Activity Iron Assimilation By Chelation And Transport Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Antifungal Humoral Response Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Osteoclast Development Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Protein Activation Cascade Negative Regulation Of Cellular Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Tissue Homeostasis Positive Regulation Of Phosphorylation Regulation Of Immune Response Central Nervous System Myelin Maintenance Platelet Activation	Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		18mg 42days 42h 48h 5ml 60days 63mum ase biomimetic biopolymers bps chondroitin factor165 glycolic glycosaminoglycan hds hyaluronic incubating lds loading mgco3 microclimate microencapsulation microspheres percolating ph7 plga sink trehalose	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Difference) ?		18mg 42days 42h 48h 5ml 60days 63mum ase biomimetic biopolymers bps chondroitin factor165 glycolic glycosaminoglycan hds hyaluronic incubating lds loading mgco3 microclimate microencapsulation microspheres percolating ph7 plga sink trehalose	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Intersection) ?