LYZ and ACE2

Number of citations of the paper that reports this interaction (PubMedID 35792074)
26

Data Source:
BioGRID (pull down)

		LYZ	ACE2
Description		lysozyme	angiotensin converting enzyme 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Cell Projection Membrane Raft Extracellular Exosome
	Molecular Function	Lysozyme Activity Catalytic Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Identical Protein Binding	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Transporter Activator Activity
	Biological Process	Inflammatory Response Antimicrobial Humoral Response Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Tryptophan Transport Viral Life Cycle Receptor-mediated Endocytosis Of Virus By Host Cell Viral Translation Regulation Of Vasoconstriction Regulation Of Cell Population Proliferation Ceramide Biosynthetic Process Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Membrane Fusion Negative Regulation Of ERK1 And ERK2 Cascade Blood Vessel Diameter Maintenance Entry Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Neutrophil degranulation Antimicrobial peptides Amyloid fiber formation	Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion
Drugs		Aspartic acid (R)-Propylene glycol 4-methyl-umbelliferyl-N-acetyl-chitobiose Sucrose Arsanilic acid 4)-N-acetyl-beta-D-glucosamine p-Toluenesulfonic acid Propyl alcohol Cu-Cyclam (S)-Aspartimide Dodecyl sulfate Triacetylchitotriose Methylumbelliferyl chitotriose UNDECA-3,7-DIENE-1,3,7,11-TETRACARBALDEHYDE	Chloroquine Hydroxychloroquine SPP1148 Bromhexine N-(2-Aminoethyl)-1-aziridineethanamine
Diseases		Familial amyloidosis
GWAS		Blood protein levels ( 30072576) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 18391951) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Response to diuretic therapy ( 18591461) Triglyceride levels ( 32203549) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: A2M ACE2 CDC42 CLU ELN LCN1 LTF	48 interacting genes: AGT AGTR1 AGTR2 APOE BTN3A1 BTN3A2 BTN3A3 CALM1 CAMP DEFA1 DEFA5 DLEU2 ELANE GHRL GRM2 H2AC4 HRH1 HSPA1A KDM1A LTF LYZ MAP4K3 MAS1 MAST1 MAST2 MMP14 NHERF1 NHERF2 NTS PARD3 PDZK1 PRMT5 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SKP2 SLC6A19 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D TMPRSS2 UBR4 USP50
Entrez ID		4069	59272
HPRD ID		01085	02274
Ensembl ID		ENSG00000090382	ENSG00000130234
Uniprot IDs		B2R4C5 P61626	A0A7I2V4H0 Q9BYF1
PDB IDs		133L 134L 1B5U 1B5V 1B5W 1B5X 1B5Y 1B5Z 1B7L 1B7M 1B7N 1B7O 1B7P 1B7Q 1B7R 1B7S 1BB3 1BB4 1BB5 1C43 1C45 1C46 1C7P 1CJ6 1CJ7 1CJ8 1CJ9 1CKC 1CKD 1CKF 1CKG 1CKH 1D6P 1D6Q 1DI3 1DI4 1DI5 1EQ4 1EQ5 1EQE 1GAY 1GAZ 1GB0 1GB2 1GB3 1GB5 1GB6 1GB7 1GB8 1GB9 1GBO 1GBW 1GBX 1GBY 1GBZ 1GDW 1GDX 1GE0 1GE1 1GE2 1GE3 1GE4 1GEV 1GEZ 1GF0 1GF3 1GF4 1GF5 1GF6 1GF7 1GF8 1GF9 1GFA 1GFE 1GFG 1GFH 1GFJ 1GFK 1GFR 1GFT 1GFU 1GFV 1HNL 1I1Z 1I20 1I22 1INU 1IOC 1IP1 1IP2 1IP3 1IP4 1IP5 1IP6 1IP7 1IWT 1IWU 1IWV 1IWW 1IWX 1IWY 1IWZ 1IX0 1IY3 1IY4 1JKA 1JKB 1JKC 1JKD 1JSF 1JWR 1LAA 1LHH 1LHI 1LHJ 1LHK 1LHL 1LHM 1LMT 1LOZ 1LYY 1LZ1 1LZ4 1LZ5 1LZ6 1LZR 1LZS 1OP9 1OUA 1OUB 1OUC 1OUD 1OUE 1OUF 1OUG 1OUH 1OUI 1OUJ 1QSW 1RE2 1REM 1REX 1REY 1REZ 1TAY 1TBY 1TCY 1TDY 1UBZ 1W08 1WQM 1WQN 1WQO 1WQP 1WQQ 1WQR 1YAM 1YAN 1YAO 1YAP 1YAQ 207L 208L 2BQA 2BQB 2BQC 2BQD 2BQE 2BQF 2BQG 2BQH 2BQI 2BQJ 2BQK 2BQL 2BQM 2BQN 2BQO 2HEA 2HEB 2HEC 2HED 2HEE 2HEF 2LHM 2MEA 2MEB 2MEC 2MED 2MEE 2MEF 2MEG 2MEH 2MEI 2NWD 2ZIJ 2ZIK 2ZIL 2ZWB 3EBA 3FE0 3LHM 3LN2 4I0C 4ML7 4R0P 5LSH 5LVK 6LFH 7AP7 7XF6 7XF7 7XF8 8QUT 8R4A	1R42 1R4L 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DDO 7DDP 7DF4 7DMU 7DQA 7DRV 7DWX 7DX4 7DX5 7DX6 7DX7 7DX8 7DX9 7E7E 7EDJ 7EFP 7EFR 7EKC 7EKE 7EKF 7EKG 7EKH 7FDG 7FDH 7FDI 7FEM 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F 7LO4 7MJM 7MJN 7NXC 7P19 7P55 7P8I 7P8J 7PKI 7R0Z 7R10 7R11 7R12 7R1A 7RPV 7SN0 7SXX 7SXY 7SXZ 7SY0 7SY1 7SY2 7SY3 7SY4 7SY5 7SY6 7SY7 7SY8 7T9K 7T9L 7TEW 7TEX 7TEZ 7TF0 7TN0 7U0N 7UFK 7UFL 7V61 7V7Z 7V80 7V81 7V82 7V83 7V84 7V85 7V86 7V87 7V88 7V89 7V8A 7V8B 7VIB 7VX4 7VX5 7VX9 7VXA 7VXB 7VXC 7VXD 7VXF 7VXK 7VXM 7W98 7W99 7W9B 7W9C 7W9I 7WBL 7WBP 7WBQ 7WGB 7WGC 7WHH 7WK4 7WK5 7WK6 7WNM 7WPA 7WPB 7WPC 7WS8 7WS9 7WSA 7WVP 7WVQ 7XAZ 7XB0 7XB1 7XBF 7XBG 7XBH 7XCH 7XCI 7XCP 7XID 7XO7 7XO8 7XO9 7XWA 7Y1Y 7Y1Z 7Y20 7Y21 7Y75 7Y76 7Y9Z 7YA0 7YA1 7YDI 7YEG 7YHW 7YJ3 7YR2 7YR3 7YR4 7ZDQ 7ZF7 8AQS 8ASY 8B9P 8BFW 8BN1 8BYJ 8DF5 8DLJ 8DLK 8DLM 8DLN 8DLP 8DLQ 8DLU 8DLV 8DM5 8DM6 8DV1 8DV2 8E7M 8FXB 8FXC 8H06 8H5C 8HRK 8HRL 8HRN 8HRU 8I91 8I92 8I93 8I9B 8I9C 8I9D 8I9E 8I9F 8I9G 8I9H 8IF2 8IOU 8IOV 8JJE 8JWH 8JYN 8JYO 8JYP 8P2W 8P2X 8P2Y 8P2Z 8P30 8P31 8QSQ 8S9G 8SPH 8SPI 8TOQ 8TOR 8TOS 8TOT 8TOU 8UZE 8VKO 8VKP 8VQR 8WBY 8WBZ 8WDR 8WDS 8WDY 8WDZ 8WE0 8WE1 8WE4 8WGV 8WGW 8WHS 8WHU 8WHZ 8WLZ 8WM3 8WP8 8WRH 8WRL 8WRM 8WRO 8WSR 8WTD 8WTJ 8WYH 8XAL 8XLM 8XLN 8XN2 8XN3 8XN5 8XNF 8XNK 8XSF 8XSJ 8XUY 8XUZ 8XV0 8XV1 8XVM 8XXW 8XY9 8XYE 8XYG 8XYO 8Y16 8Y18 8Y6A 8YZB 8YZC 8YZD 8YZE 8Z3W 8Z4X 8Z64 8Z6A 8Z7B 8Z7P 8ZBQ 9FMM 9IU1 9IUP 9IUQ 9IUU 9JJ6
Enriched GO Terms of Interacting Partners?		Extracellular Region Negative Regulation Of Complement Activation Regulation Of Complement Activation Extracellular Space Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Humoral Immune Response Regulation Of Cell Population Proliferation Signaling Receptor Binding Platelet Alpha Granule Lumen Extracellular Exosome Negative Regulation Of Complement Activation, Lectin Pathway Cell Periphery Host-mediated Perturbation Of Viral Process Regulation Of Protein-containing Complex Assembly Circulatory System Process GBD Domain Binding Storage Vacuole Regulation Of Supramolecular Fiber Organization Host-mediated Perturbation Of Symbiont Process Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neuronal Signal Transduction Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Immune System Process Modulation Of Process Of Another Organism Blood Microparticle Interleukin-8 Binding Striated Muscle Tissue Development Endothelin Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Positive Regulation Of Bone Mineralization Involved In Bone Maturation Entry Receptor-mediated Virion Attachment To Host Cell Apolipoprotein A-I Receptor Binding Muscle Tissue Development Anatomical Structure Morphogenesis Neuropilin Signaling Pathway System Process Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Regulation Of Smooth Muscle Cell Proliferation	Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Angiotensin Type II Receptor Activity Plasma Membrane Biological Process Involved In Interaction With Symbiont Killing By Host Of Symbiont Cells Killing Of Cells Of Another Organism Synaptic Receptor Adaptor Activity Positive Regulation Of Signaling Angiotensin-activated Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cytokine Production Signal Transduction Regulation Of System Process Defense Response To Fungus Positive Regulation Of Cell Communication Vascular Process In Circulatory System Response To Fungus Cell Killing Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Nitric Oxide-cGMP-mediated Signaling Circulatory System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Signaling Positive Regulation Of Signal Transduction Serine-type Endopeptidase Activity Antimicrobial Humoral Response Defense Response To Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Type 2 Metabotropic Glutamate Receptor Binding Positive Regulation Of Cytokine Production Positive Regulation Of Developmental Process Low-density Lipoprotein Particle Remodeling Localization Within Membrane Regulation Of Cell Communication Brush Border Membrane Defense Response To Gram-positive Bacterium Renin-angiotensin Regulation Of Aldosterone Production Nitric Oxide Mediated Signal Transduction Extracellular Exosome Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Synaptic Plasticity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Specific Granule Lumen Type 3 Metabotropic Glutamate Receptor Binding
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