LYZ and ELN

Number of citations of the paper that reports this interaction (PubMedID 9745729)
0

Data Source:
HPRD (in vivo)

		LYZ	ELN
Description		lysozyme	elastin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Extracellular Matrix Elastic Fiber
	Molecular Function	Lysozyme Activity Catalytic Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Identical Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Inflammatory Response Antimicrobial Humoral Response Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly
Pathways		Neutrophil degranulation Antimicrobial peptides Amyloid fiber formation	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Aspartic acid (R)-Propylene glycol 4-methyl-umbelliferyl-N-acetyl-chitobiose Sucrose Arsanilic acid 4)-N-acetyl-beta-D-glucosamine p-Toluenesulfonic acid Propyl alcohol Cu-Cyclam (S)-Aspartimide Dodecyl sulfate Triacetylchitotriose Methylumbelliferyl chitotriose UNDECA-3,7-DIENE-1,3,7,11-TETRACARBALDEHYDE	Rofecoxib
Diseases		Familial amyloidosis	Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis
GWAS		Blood protein levels ( 30072576) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 18391951) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Response to diuretic therapy ( 18591461) Triglyceride levels ( 32203549) White blood cell count ( 32888494)	Diverticular disease ( 30177863) Height ( 31562340)
Interacting Genes		7 interacting genes: A2M ACE2 CDC42 CLU ELN LCN1 LTF	25 interacting genes: ARLN ASS1 ATP2A2 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PLN PRTN3 SPINK1
Entrez ID		4069	2006
HPRD ID		01085	00556
Ensembl ID		ENSG00000090382	ENSG00000049540
Uniprot IDs		B2R4C5 P61626	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs		133L 134L 1B5U 1B5V 1B5W 1B5X 1B5Y 1B5Z 1B7L 1B7M 1B7N 1B7O 1B7P 1B7Q 1B7R 1B7S 1BB3 1BB4 1BB5 1C43 1C45 1C46 1C7P 1CJ6 1CJ7 1CJ8 1CJ9 1CKC 1CKD 1CKF 1CKG 1CKH 1D6P 1D6Q 1DI3 1DI4 1DI5 1EQ4 1EQ5 1EQE 1GAY 1GAZ 1GB0 1GB2 1GB3 1GB5 1GB6 1GB7 1GB8 1GB9 1GBO 1GBW 1GBX 1GBY 1GBZ 1GDW 1GDX 1GE0 1GE1 1GE2 1GE3 1GE4 1GEV 1GEZ 1GF0 1GF3 1GF4 1GF5 1GF6 1GF7 1GF8 1GF9 1GFA 1GFE 1GFG 1GFH 1GFJ 1GFK 1GFR 1GFT 1GFU 1GFV 1HNL 1I1Z 1I20 1I22 1INU 1IOC 1IP1 1IP2 1IP3 1IP4 1IP5 1IP6 1IP7 1IWT 1IWU 1IWV 1IWW 1IWX 1IWY 1IWZ 1IX0 1IY3 1IY4 1JKA 1JKB 1JKC 1JKD 1JSF 1JWR 1LAA 1LHH 1LHI 1LHJ 1LHK 1LHL 1LHM 1LMT 1LOZ 1LYY 1LZ1 1LZ4 1LZ5 1LZ6 1LZR 1LZS 1OP9 1OUA 1OUB 1OUC 1OUD 1OUE 1OUF 1OUG 1OUH 1OUI 1OUJ 1QSW 1RE2 1REM 1REX 1REY 1REZ 1TAY 1TBY 1TCY 1TDY 1UBZ 1W08 1WQM 1WQN 1WQO 1WQP 1WQQ 1WQR 1YAM 1YAN 1YAO 1YAP 1YAQ 207L 208L 2BQA 2BQB 2BQC 2BQD 2BQE 2BQF 2BQG 2BQH 2BQI 2BQJ 2BQK 2BQL 2BQM 2BQN 2BQO 2HEA 2HEB 2HEC 2HED 2HEE 2HEF 2LHM 2MEA 2MEB 2MEC 2MED 2MEE 2MEF 2MEG 2MEH 2MEI 2NWD 2ZIJ 2ZIK 2ZIL 2ZWB 3EBA 3FE0 3LHM 3LN2 4I0C 4ML7 4R0P 5LSH 5LVK 6LFH 7AP7 7XF6 7XF7 7XF8 8QUT 8R4A
Enriched GO Terms of Interacting Partners?		Extracellular Region Negative Regulation Of Complement Activation Regulation Of Complement Activation Extracellular Space Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Humoral Immune Response Regulation Of Cell Population Proliferation Signaling Receptor Binding Platelet Alpha Granule Lumen Extracellular Exosome Negative Regulation Of Complement Activation, Lectin Pathway Cell Periphery Host-mediated Perturbation Of Viral Process Regulation Of Protein-containing Complex Assembly Circulatory System Process GBD Domain Binding Storage Vacuole Regulation Of Supramolecular Fiber Organization Host-mediated Perturbation Of Symbiont Process Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neuronal Signal Transduction Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Immune System Process Modulation Of Process Of Another Organism Blood Microparticle Interleukin-8 Binding Striated Muscle Tissue Development Endothelin Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Positive Regulation Of Bone Mineralization Involved In Bone Maturation Entry Receptor-mediated Virion Attachment To Host Cell Apolipoprotein A-I Receptor Binding Muscle Tissue Development Anatomical Structure Morphogenesis Neuropilin Signaling Pathway System Process Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Regulation Of Smooth Muscle Cell Proliferation	Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Microfibril Extracellular Matrix Organization Extracellular Structure Organization Calcium Ion-transporting ATPase Complex Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Basement Membrane Extracellular Matrix Binding Regulation Of Multicellular Organismal Process Calcium Ion Binding Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Regulation Of Cardiac Muscle Cell Membrane Potential Humoral Immune Response Killing Of Cells Of Another Organism Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Calcium Ion Import Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Collagen Fibril Organization Extracellular Negative Regulation Of Signal Transduction Relaxation Of Cardiac Muscle Extracellular Matrix Structural Constituent Conferring Compression Resistance Sensory Organ Morphogenesis Cell Killing Negative Regulation Of Calcium Ion Import Azurophil Granule Lumen Relaxation Of Muscle Negative Regulation Of Heart Contraction Response To External Biotic Stimulus Extracellular Exosome Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Circulation Glycosaminoglycan Binding Muscle Cell Cellular Homeostasis Regulation Of The Force Of Heart Contraction Defense Response To Symbiont Negative Regulation Of Signal Transduction Defense Response To Other Organism Extracellular Matrix Assembly Embryonic Organ Morphogenesis Fibronectin Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Endocytosis
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