AQP8 and STX12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP8	STX12
Description		aquaporin 8	syntaxin 12
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Smooth Endoplasmic Reticulum Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Smooth Endoplasmic Reticulum Membrane Brush Border Membrane Mitochondrial Membrane Apical Part Of Cell Intracellular Canaliculus Intracellular Vesicle	Golgi Membrane Phagophore Assembly Site Nucleoplasm Endosome Golgi Apparatus Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Synaptic Vesicle Membrane BLOC-1 Complex SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Vesicle Membrane Raft Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Postsynaptic Recycling Endosome
	Molecular Function	Protein Binding Ammonium Channel Activity Water Channel Activity Methylammonium Channel Activity Urea Channel Activity Channel Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Water Transport Urea Transport Methylammonium Transport One-carbon Compound Transport B Cell Differentiation Transepithelial Water Transport Regulation Of Cholesterol Biosynthetic Process Transmembrane Transport Cellular Response To CAMP Urea Transmembrane Transport Ammonium Transmembrane Transport Methylammonium Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Ammonium Import Across Plasma Membrane Cellular Detoxification	Autophagosome Assembly Intracellular Protein Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Endocytic Recycling Cholesterol Efflux Vesicle Docking Protein Stabilization Regulation Of Biological Quality
Pathways		Detoxification of Reactive Oxygen Species Passive transport by Aquaporins Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856)
Interacting Genes		6 interacting genes: CYBC1 PLP2 PLPP6 SERP1 STX12 TMEM120B	44 interacting genes: AQP6 AQP8 BCL2L13 BLOC1S6 CD79A CISD2 DNAJC5 DTX2 EBP EEA1 EPB42 ERGIC3 FAM209A FCER1G GORAB HOMER1 KASH5 LEPROTL1 LMNA MFSD6 MMGT1 NAPA NEMP1 NSG1 PDZK1IP1 PLPPR2 RIC3 SEC11C SLC10A1 SLC10A6 SLC66A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STXBP5L TIMMDC1 TLCD4 TMEM14B TMEM167B TMEM31 TMEM86B TMX2
Entrez ID		343	23673
HPRD ID		04778	06059
Ensembl ID		ENSG00000103375	ENSG00000117758
Uniprot IDs		O94778	Q86Y82
PDB IDs			2DNX
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Nuclear Inner Membrane Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Endoplasmic Reticulum Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Chemokine Binding Postsynaptic Recycling Endosome Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion Respiratory Burst Involved In Defense Response Respiratory Burst After Phagocytosis Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Protein Prenylation Lysophosphatidic Acid Phosphatase Activity Regulation Of Neutrophil Activation Monoatomic Ion Transmembrane Transporter Activity Membrane Regulation Of Growth Hormone Secretion Phosphatidate Phosphatase Activity	Membrane SNARE Complex Exocytosis Membrane Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane SNAP Receptor Activity Membrane Organization Secretion By Cell Synaptic Vesicle Membrane Organization Synaptic Vesicle Priming Vesicle-mediated Transport Vesicle Fusion Syntaxin Binding Organelle Membrane Fusion Secretion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Docking Synaptic Vesicle Docking Vesicle Organization Vesicle Docking Establishment Of Localization In Cell Organelle Localization SNARE Binding Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Presynaptic Active Zone Membrane Signal Release Bile Acid:sodium Symporter Activity Cellular Localization Synaptic Vesicle Exocytosis Vesicle-mediated Transport In Synapse Mitochondrial Membrane ATP-dependent Protein Binding Regulated Exocytosis Vesicle Docking Involved In Exocytosis Ammonium Channel Activity Cytoplasmic Vesicle Ammonium Transmembrane Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Presynapse Regulation Of Synaptic Vesicle Priming Water Channel Activity Tertiary Granule Membrane Intracellular Transport BLOC-1 Complex Vesicle Targeting Somatodendritic Compartment
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