CLEC4M and ITGAM

Number of citations of the paper that reports this interaction (PMID 16246332)
17

Data Source:
HPRD (in vitro)

		CLEC4M	ITGAM
Gene Name		C-type lectin domain family 4, member M	integrin, alpha M (complement component 3 receptor 3 subunit)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Integral Component Of Plasma Membrane Membrane	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Mannose Binding Carbohydrate Binding ICAM-3 Receptor Activity Peptide Antigen Binding Virion Binding Metal Ion Binding Calcium-dependent Protein Binding	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Endocytosis Leukocyte Cell-cell Adhesion Cell-cell Recognition Regulation Of Gene Expression Modulation By Virus Of Host Morphology Or Physiology Virion Attachment To Host Cell Viral Genome Replication Antigen Processing And Presentation Regulation Of Blood Coagulation Intracellular Signal Transduction Innate Immune Response Peptide Antigen Transport Intracellular Transport Of Virus	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		3 interactors: CD209 ICAM3 ITGAM	18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1
Entrez ID		10332	3684
HPRD ID		12060	00411
Ensembl ID		ENSG00000104938	ENSG00000169896
Uniprot IDs		B4E2Z5 H7BXU4 Q9H2X3	P11215
PDB IDs		1K9J 1SL6 1XAR 1XPH 1Z0Y 3JQH	1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Cell Adhesion Regulation Of Immune System Process Microglia Development Peptide Antigen Transport Leukocyte Cell-cell Adhesion Ectodermal Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Virion Attachment To Host Cell Adhesion Of Symbiont To Host Leukocyte Migration Involved In Inflammatory Response Macrophage Differentiation Modulation By Virus Of Host Morphology Or Physiology Ectoderm Development Viral Genome Replication Innate Immune Response Intracellular Transport Of Virus Cellular Extravasation Activated T Cell Proliferation Regulation Of Immune Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Cell-cell Recognition Immune Response T Cell Proliferation Defense Response Toll-like Receptor 4 Signaling Pathway Peptide Transport Interaction With Host Glial Cell Development Leukocyte Chemotaxis Toll-like Receptor Signaling Pathway Lymphocyte Proliferation Myeloid Leukocyte Differentiation Mononuclear Cell Proliferation Leukocyte Proliferation Cell Recognition Integrin-mediated Signaling Pathway Amide Transport Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of T Cell Proliferation Cell Chemotaxis	Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade
Tagcloud ?		affinities apo assignment carbohydrates cd209l cd299 certainty compartments crd dc debate dendritic endocytic endosomal glcnac glycan glycans grabbing homologue integrin intercellular lectin mannose moieties oligosaccharides recycling releases reversibly signr	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?		affinities apo assignment carbohydrates cd209l cd299 certainty compartments crd dc debate dendritic endocytic endosomal glcnac glycan glycans grabbing homologue intercellular lectin mannose moieties oligosaccharides recycling releases reversibly signr	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?		integrin